AI Article Synopsis
- The study investigated the effects of mild hypobaric hypoxia preconditioning on brain health and behavior in rats subjected to severe hypoxia.
- The severe hypoxia caused significant neuronal loss in the hippocampus, but the mild preconditioning offered protective benefits to these vulnerable cells.
- Additionally, preconditioning improved learning and memory retention in passive avoidance tasks, with more trials showing better results in preventing deficits due to severe hypoxia.
Article Abstract
The aim of this work was to study effects of mild preconditioning hypobaric hypoxia (380 Torr for 2 h, repeated 3 or 6 times spaced at 24 h) on brain NGFI-A immunoreactivity and passive avoidance (PA) behavior in rats exposed to severe hypoxia (160 Torr for 3 h). Severe hypobaric hypoxia produced extensive neuronal loss in hippocampal CA1, while the preceding hypoxic preconditioning had clear protective effect on neuronal viability of vulnerable hippocampal cells. Besides, the hypoxic preconditioning prevented impairment of acquisition and retention of PA caused by severe hypoxia. The six-trial hypobaric preconditioning was more effective in protection against PA learning deficits in severe hypoxia exposed rats than the three-trial preconditioning. The preconditioning up-regulated severe hypoxia-suppressed neocortical and hippocampal expression of NGFI-A, suggesting a possible role for NGFI-A in the neuroprotective mechanisms activated by hypoxic preconditioning.
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| http://dx.doi.org/10.1016/j.bbr.2004.11.023 | DOI Listing |
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