A new xanthone compound named retymicin (1) was isolated together with galtamycin B (2) and saquayamycin Z (3), new members of the galtamycin and saquayamycin families, respectively, and the new lumichrome derivative 1-(alpha-ribofuranosyl)-lumichrome (4) from Micromonospora strain Tü 6368, isolated from a soil sample collected in Romania. Retymicin, galtamycin B and saquayamycin Z show cytostatic effects to various human tumor cell lines whereas saquayamycin Z is also active against Gram-positive bacteria.
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http://dx.doi.org/10.1038/ja.2005.12 | DOI Listing |
Mar Drugs
May 2019
College of Marine Science, Shandong University at Weihai, Weihai 264209, China.
Four angucycline glycosides were previously characterized from marine-derived sp. OC1610.4.
View Article and Find Full Text PDFMar Drugs
November 2018
Department of Pharmacy, College of Marine Science, Shandong University, Weihai 264209, China.
Four angucycline glycosides including three new compounds landomycin N (), galtamycin C () and vineomycin D (), and a known homologue saquayamycin B (), along with two alkaloids 1-acetyl-β-carboline () and indole-3-acetic acid (), were isolated from the fermentation broth of an intertidal sediments-derived sp. Their structures were established by IR, HR-ESI-MS, 1D and 2D NMR techniques. Among the isolated angucyclines, saquayamycin B () displayed potent cytotoxic activity against hepatoma carcinoma cells HepG-2, SMMC-7721 and plc-prf-5, with IC values 0.
View Article and Find Full Text PDFChembiochem
May 2009
Albert-Ludwigs-Universität, Institut für Pharmazeutische Wissenschaften, Pharmazeutische Biologie und Biotechnologie, Stefan-Meier-Strasse 19, 79104 Freiburg, Germany.
Sweet ways: We have investigated the glycosyltransferase genes of the saquayamycin Z (shown) and galtamycin B biosynthetic gene cluster from Micromonospora sp. Tü6368. The results unambiguously show that both compounds are derived from the same cluster.
View Article and Find Full Text PDFJ Antibiot (Tokyo)
February 2005
Institut für Organische und Biomolekulare Chemie, Universität Gottingen, Tammannstr. 2, D-37077 Göttingen, Germany.
A detailed screening of the secondary metabolite pattern from Micromonospora sp. strain Tü 6368 resulted in the isolation of ten compounds belonging to five different structural families. The structures of the novel compounds 1-(alpha-ribofuranosyl)-lumichrome (3), retymicin (7), galtamycin B (11) and saquayamycin Z (14) were assigned by spectroscopic methods and chemical transformations.
View Article and Find Full Text PDFJ Antibiot (Tokyo)
February 2005
Mikrobiologisches Institut, Universität Tübingen, Auf der Morgenstelle 28, D-72076 Tübingen, Germany.
A new xanthone compound named retymicin (1) was isolated together with galtamycin B (2) and saquayamycin Z (3), new members of the galtamycin and saquayamycin families, respectively, and the new lumichrome derivative 1-(alpha-ribofuranosyl)-lumichrome (4) from Micromonospora strain Tü 6368, isolated from a soil sample collected in Romania. Retymicin, galtamycin B and saquayamycin Z show cytostatic effects to various human tumor cell lines whereas saquayamycin Z is also active against Gram-positive bacteria.
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