AI Article Synopsis
- The zebrafish, Brachydanio rerio, serves as an effective model to investigate organ development, particularly in retinal structures.
- By using electron microscopy, researchers analyzed Müller cell processes in zebrafish retinas, revealing multiple layers alongside synaptic terminal endings in the outer nuclear layer.
- This study is groundbreaking as it provides the first detailed view of the ultrastructural arrangement of Müller cell processes around the outer limiting membrane and photoreceptor layers in zebrafish.
Article Abstract
The zebrafish, Brachydanio rerio, is a good model for studying the development of various organs. We have assayed the distribution pattern of Müller cell processes in zebrafish retinas by electron microscopy. In the outer nuclear (ON) layer, multiple layers of Müller cell processes were present along both sides of the large pyramidal endings of the synaptic terminals. We found that the inner segments (ISs) of the zebrafish photoreceptors (PRs), including the cones, double cones and rods, were arranged in different planes, and that the Müller cell processes formed multilayered sheaths around virtually all PR compartments except their outer segments. Thus, Müller cell processes beyond the outer limiting membrane (OLM) are more easily observed in zebrafish retina than in the retinas of other species. To our knowledge, this is the first study to show the exact ultrastructural distribution of Müller cell processes around the OLM and the PR layer in zebrafish retina.
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| http://dx.doi.org/10.1016/j.aanat.2004.08.006 | DOI Listing |
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