We reported a 36-year-old man, who suffered from cluster headache (CH) associated with hemicrania continua (HC). The continuous, dull or pressure-type headache appeared on the same side of the CH during the third month of a prolonged cluster period, and fluctuated in the severity of pain. This headache was aggravated when the CH was ameliorated by the administration of lithium carbonate. This converse relationship between CH and HC persisted during an on-off trial of the lithium carbonate, and the HC was exacerbated again after the complete cessation of CH. Retrobulbar pain and nasal congestion were present as components of HC similarly to CH, but they subsided gradually and the pressure-type vascular headache over the temporal area predominated later. The continuous headache lasted more than 3 months, and responded significantly to the indomethacin at a dose of 75mg/d. The clinical course of this patient suggests that HC and CH have a common pathomechanism including hyperactivation of the trigemino-vascular reflex, and may be different in the involvement of other central pathway of pain generation. Indomethacin may deserve consideration for the treatment of continuous headache that appears during an atypical course of other primary headaches.
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Int J Infect Dis
February 2025
Kenya Medical Research Institute/Walter Reed Army Institute of Research - Africa/Basic Science Laboratory, Kisumu, Kenya. Electronic address:
Objectives: We report the first confirmed cases of Zika virus disease (ZVD) in Kenya and provide the associated genomic sequences.
Design: The study is part of a prospective febrile illness surveillance study in Kenya.
Methods: A cluster of ZVD was identified in febrile patients presenting at King Fahd Referral Hospital, Lamu Island.
Curr Pain Headache Rep
February 2025
Department of Neurology, Mount Sinai Hospital, Icahn School of Medicine at Mount Sinai, New York, USA.
Purpose Of Review: Artificial intelligence (AI) has impacted different aspects of headache medicine, from history taking and diagnosis to drug development. AI has been shown to have predictive modeling in helping diagnose migraine and assist with patient care. Additionally, this technology has been adapted to help non-headache specialists with headache management.
View Article and Find Full Text PDFJ Clin Med
February 2025
Department of Medicine, Veterans Affairs Medical Center, Washington, DC 20422, USA.
Anti-amyloid therapies (AATs) are increasingly being recognized as promising treatment options for Alzheimer's disease (AD). Amyloid-related imaging abnormalities (ARIAs), small areas of edema and microbleeds in the brain presenting as abnormal signals in MRIs of the brain for patients with AD, are the most common side effects of AATs. While most ARIAs are asymptomatic, they can be associated with symptoms like nausea, headache, confusion, and gait instability and, less commonly, with more serious complications such as seizures and death.
View Article and Find Full Text PDFIntroduction: Migraine and other types of primary headache are widely prevalent and are thought to have substantial economic implications on a global scale. Nevertheless, the precise prevalence rates in China exhibited discrepancies across various studies. The present study aimed to ascertain the prevalence of migraine and other primary headache disorders in China.
View Article and Find Full Text PDFPain Ther
February 2025
Kiel Migraine and Headache Centre, Heikendorfer Weg 9-27, 24149, Kiel, Germany.
Introduction: The specific headache phenotype, accompanying symptoms and psychological impact that lead to admission of patients with cluster headache are not yet known. The aim of this study was therefore to analyze the characteristics of patients who were admitted to a tertiary headache center in 2018, 2019 and 2020 due to cluster headache.
Methods: A total of 207 patients with cluster headache were examined, who were admitted to the Kiel Headache Center, a tertiary headache center in Germany, in the years 2018, 2019, and 2020.
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