The intrinsic ability of amino acids to catalyze the asymmetric formation of carbohydrates, which enzymes have mediated for millions of years, with significant amplification of enantiomeric excess suggests a plausible ancient catalytic process for the evolution of homochirality.

Download full-text PDF

Source
http://dx.doi.org/10.1039/b500589bDOI Listing

Publication Analysis

Top Keywords

plausible origins
4
origins homochirality
4
homochirality amino
4
amino acid
4
acid catalyzed
4
catalyzed neogenesis
4
neogenesis carbohydrates
4
carbohydrates intrinsic
4
intrinsic ability
4
ability amino
4

Similar Publications

Genetic diversity and intercontinental dispersal of temperate and subarctic populations of Dibothriocephalus dendriticus (Cestoda; Diphyllobothriidea), a causative agent of dibothriocephalosis.

Int J Parasitol

January 2025

Institute of Parasitology, Biology Centre, Czech Academy of Sciences, Branišovská 31 37005 České Budějovice, Czech Republic; Faculty of Science, University of South Bohemia, Branišovská 1760, 37005 České Budějovice, Czech Republic. Electronic address:

The diphyllobothriid tapeworm Dibothriocephalus dendriticus, one of the causative agents of the fish-borne zoonosis dibothriocephalosis, is mainly distributed in the Arctic/subarctic and temperate zones of the Northern Hemisphere (Europe, North America, and Asia), but also in the southern cone region of South America (Patagonia). The genetic structure and gene flow among 589 individuals of D. dendriticus, representing 20 populations, were studied using the mitochondrial cox1 gene as the first choice marker and 10 polymorphic nuclear microsatellite loci as a dominant molecular tool.

View Article and Find Full Text PDF

Mammalian blood cells originate from specialized 'hemogenic' endothelial (HE) cells in major arteries. During the endothelial-to-hematopoietic transition (EHT), nascent hematopoietic stem cells (HSCs) bud from the arterial endothelial wall and enter circulation, destined to colonize the fetal liver before ultimately migrating to the bone marrow. Mechanisms and processes that facilitate EHT and the release of nascent HSCs are incompletely understood, but may involve signaling from neighboring vascular endothelial cells, stromal support cells, circulating pre-formed hematopoietic cells, and/or systemic factors secreted by distal organs.

View Article and Find Full Text PDF

Concomitant formation of protocells and prebiotic compounds under a plausible early Earth atmosphere.

Proc Natl Acad Sci U S A

January 2025

Laboratory of Crystallographic Studies, Instituto Andaluz de Ciencias de la Tierra, Consejo Superior de Investigaciones Científica, Armilla 18100, Spain.

Revealing the origin of life and unambiguously detecting fossil remains of the earliest organisms are closely related aspects of the same scientific research. The synthesis of prebiotic molecular building blocks of life and the first compartmentalization into protocells have been considered two events apart in time, space, or both. We conducted lightning experiments in borosilicate reactors filled with a mixture of gases mimicking plausible geochemical conditions of early Earth.

View Article and Find Full Text PDF

Human induced pluripotent stem cell (hiPSC)-based disease modeling can be successfully recapitulated to mimic disease characteristics across various human pathologies. Glaucoma, a progressive optic neuropathy, primarily affects the retinal ganglion cells (RGCs). While multiple groups have successfully generated RGCs from non-diseased hiPSCs, producing RGCs from glaucomatous human samples holds significant promise for understanding disease pathology by revealing patient-specific disease signatures.

View Article and Find Full Text PDF

Background: This article is dedicated to David Farrington who was a giant in criminology and, in particular, a pioneer in studying developmental pathways of delinquent and antisocial behaviour. Numerous studies followed his work. Systematic reviews of his and others' research described between two and seven (mainly 3-5) trajectories.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!