Hemopoetic organs damage syndrome in patients with chronic viral hepatitis.

Liver cirrhosis and hepatocellular carcinoma are the most frequent and severe complications of chronic hepatitis C. Results of recent investigations indicate that HCV persists and replicates not only in hepatic tissue, but in the other organs as well. The goal of our investigation was to determine hematological disorders during chronic HCV and HCV+HBV hepatitis, to find correlation between activity of chronic hepatitis, stage of cirrhosis, and degree of hematological disorders. We have studied patients with chronic C and B+C hepatitis (36 persons) and 77 HCV-infected persons on the stage of cirrhosis. The erythrocytes morphology was investigated using light microscope. The osmotic resistance of erythrocytes was investigated using the method of Ianovski (modification of Ribiera); the thrombocytes' ability to adhere and aggregate was studied by Rite's method. The absolute number of thrombocytes was counted by means of phase-contrast microscope. Our investigation suggests that there is no absolute correlation between chronic hepatitis C activity and hematological disorders and often the degree of extrahepatocellular disorders is higher than the degree of liver damage.