Confocal laser scanning microscopy has been used to obtain 3D optical image stacks of packings of glass ballotini in various fluorescent dye-containing fluids inside a 3D micromodel. The fluids' refractive index was matched to that of the glass ballotini so that clear images at an appreciable depth (approximately 400 microm) inside the packings were obtained. The lattice Boltzmann method was then used to produce 3D velocity fields through the 3D image stacks of the packed ballotini. These have been used in conjunction with a stochastic random-walk algorithm to produce simulated displacement propagators, which have been shown to be in qualitative agreement with experimental propagators, obtained using nuclear magnetic resonance, of water flowing through the exact same micromodel.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.mri.2004.11.055 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The Effect of Autologous Serum Tears 50% on the Ocular Surface of Patients With Severe Dry Eye Disease due to Sjogren Syndrome: A Prospective, Double-Blind, Randomized, Controlled, Contralateral Eye Study.
Cornea
January 2025
Department of Ophthalmology, University of Cyprus Medical School, Nicosia, Cyprus.
Purpose: To assess the impact of autologous serum (AS) tears at a 50% concentration on the ocular surface of patients with refractory dry eye disease (DED) because of Sjogren syndrome.
Methods: Twenty eyes of ten patients with severe immune-mediated DED were contralaterally randomized to receive either AS tears 50% or artificial tears between June 2021 and May 2023. Changes in tear stability, ocular surface staining, and in the morphology of the corneal sub-basal nerves were evaluated before treatment and at 1, 2, and 3 months after treatment using objective tests for DED and confocal microscopy.
New quinazolone-sulfonate conjugates with an acetohydrazide linker as potential antimicrobial agents: design, synthesis and molecular docking simulations.
RSC Adv
January 2025
Department of Therapeutic Chemistry, Pharmaceutical and Drug Industries Research Institute, National Research Centre Dokki Giza 12622 Egypt
A novel molecular design based on a quinazolinone scaffold was developed the attachment of aryl alkanesulfonates to the quinazolinone core through a thioacetohydrazide azomethine linker, leading to a new series of quinazolinone-alkanesulfonates 5a-r. The antimicrobial properties of the newly synthesized quinazolinone derivatives 5a-r were investigated to examine their bactericidal and fungicidal activities against bacterial pathogens like , (Gram-positive), , , (Gram-negative), in addition to (unicellular fungal). The tested compounds demonstrated reasonable bactericidal activities compared to standard drugs.
View Article and Find Full Text PDFA Bioinspired Virus-Like Mechano-Bactericidal Nanomotor for Ocular Multidrug-Resistant Bacterial Infection Treatment.
Adv Mater
January 2025
Eye Institute of Shandong First Medical University, State Key Laboratory Cultivation Base, Shandong Key Laboratory of Eye Diseases, School of Ophthalmology, Shandong First Medical University, Qingdao, 266071, P. R. China.
Multidrug-resistant (MDR) bacteria and their associated biofilms are major causative factors in eye infections, often resulting in blindness and presenting considerable global health challenges. Presently, mechano-bactericidal systems, which combine distinct topological geometries with mechanical forces to physically induce bacterial apoptosis, show promising potential. However, the physical interaction process between current mechano-bactericidal systems and bacteria is generally based on passive diffusion or Brownian motion and lacks the force required for biofilm penetration; thus, featuring low antibacterial efficacy.
View Article and Find Full Text PDFImpact of vial quality on interactions, particle formation, container closure integrity, and gas permeability for frozen drug product storage.
Eur J Pharm Sci
January 2025
Ludwig-Maximilians-Universität München, Department of Pharmacy, Pharmaceutical Technology and Biopharmaceutics, 81377 Munich, Germany. Electronic address:
The frozen storage of biopharmaceuticals brings new challenges to the primary packaging material. Due to an increasing demand and the downsides of standard type I glass vials, such as vial breakage, novel vial types for special applications of parenteral drug products have been introduced to the market in the past years. Mechanical stresses due to dimensional changes experienced during freezing and thawing could change the material properties, hence affecting the interaction with the drug product stored in the vial or functionality such as overall integrity.
View Article and Find Full Text PDFA framework of multi-view machine learning for biological spectral unmixing of fluorophores with overlapping excitation and emission spectra.
Brief Bioinform
November 2024
Department of Biology, University at Albany, SUNY, 1400 Washington Ave, Albany, NY 12222, United States.
The accuracy of assigning fluorophore identity and abundance, known as spectral unmixing, in biological fluorescence microscopy images remains a significant challenge due to the substantial overlap in emission spectra among fluorophores. In traditional laser scanning confocal spectral microscopy, fluorophore information is acquired by recording emission spectra with a single combination of discrete excitation wavelengths. However, organic fluorophores possess characteristic excitation spectra in addition to their unique emission spectral signatures.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!