[Expression and significance of PTEN and caspase-3 in laryngeal squamous cell carcinoma].

Objective: To elucidate the expression and significance of PTEN and Caspase-3 in laryngeal squamous cell carcinoma.

Method: Immunochemical method was used to study 289 cases of laryngeal carcinoma, including 60 cases atypical hyperplasia of vocal fold and 20 cases of normal laryngeal tissues.

Result: The PTEN gene was expressed in 58.8% laryngeal carcinoma tissues, in 86.7% atypical hyperplasia of vocal fold and 100.0% normal laryngeal tissues. The differences were significance (P < 0.05). The Caspase-3 was expressed in 48.1% laryngeal carcinoma tissues, in 61.7% atypical hyperplasia of vocal fold and in 85.0% normal laryngeal tissues. The differences were significance (P < 0.05). In addition, there was a positive correlation between the expression of Caspase-3 and PTEN (P < 0.01).

Conclusion: Expression of PTEN and Caspase-3 in laryngeal carcinoma is different from that of normal laryngeal tissues, which may play an important role in the tumorigenesis and development of laryngeal carcinoma.