AI Article Synopsis
- The study examined 132 children with arthritis to investigate the link between HIV infection and arthritis.
- Among the children, 27% were HIV infected, showing a higher prevalence in males, with a significant portion presenting arthritis as their first symptom of HIV.
- The findings suggest a likely causal relationship between HIV infection and arthritis, as those infected exhibited more 'spondyloarthropathy-like' traits compared to HIV-uninfected children.
Article Abstract
Objectives: To compare human immunodeficiency virus (HIV)-infected and HIV-uninfected children with arthritis of unknown origin to determine whether the association between HIV infection and arthritis is causal or coincidental.
Method: Retrospective review of 132 children with arthritis who were tested for HIV infection.
Results: Thirty-five (27%) of the children were HIV infected and the male to female ratio was 2.5:1 (P = 0.02). Arthritis was the presenting feature of HIV infection in 78% of these children. The remaining 97 (73%) were diagnosed as having juvenile idiopathic arthritis. 'Spondyloarthropathy-like' features were found in 34% of HIV-infected children compared with 5% of uninfected children.
Conclusion: The high prevalence of HIV infection in 27% of children, the predominance of males and the increased prevalence of 'spondyloarthropathy-like' features, supports a causal relationship between HIV infection and arthritis.
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| http://dx.doi.org/10.1093/rheumatology/keh636 | DOI Listing |
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