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Isotretinoin (13-cis-retinoic acid) associated atrial tachycardia. | LitMetric

Isotretinoin (13-cis-retinoic acid) associated atrial tachycardia.

Pacing Clin Electrophysiol

Department of Cardiology, Ege University School of Medicine, Bornova, Izmir 35100, Turkey.

Published: April 2005

AI Article Synopsis

  • A 16-year-old boy experienced palpitations for a week while taking isotretinoin for acne, after three months of treatment.
  • Holter monitoring revealed he had frequent premature atrial beats and non-sustained atrial tachycardia, which he had never experienced before.
  • His symptoms nearly disappeared within a week after stopping the medication, indicating that isotretinoin may have caused the heart issues, suggesting that doctors should be cautious about its potential arrhythmogenic effects.

Article Abstract

We describe a 16-year-old boy who presented with palpitations for 1 week while being on isotretinoin treatment for nodulocystic facial acne for 3 months. Twenty four-hour Holter monitoring showed frequent premature atrial beats and episodes of nonsustained atrial tachycardia. He never had any episodes of palpitations previously. His complaints almost disappeared within a week after stopping the treatment. He remained asymptomatic since the discontinuation of the drug. The temporal relationship between isotretinoin treatment and patient's symptoms in the presence of documented arrhythmia suggests a drug-related cause. As a result, clinicians should be aware of the possible arrhythmogenic effect of isotretinoin.

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Source
http://dx.doi.org/10.1111/j.1540-8159.2005.09365.xDOI Listing

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