Clinical response to thymectomy in patients with myasthenia gravis varies in terms of timing and degree of improvement. Electrophysiological test is a reasonably reliable and objective way to evaluate neuromuscular transmission in these patients. The purpose of this study was to evaluate the electrophysiological response before and after thymectomy by repetitive nerve stimulation test in order to estimate the timing of initial improvement, progress and degree of improvement after thymectomy. According to electrophysiological findings, it appeared that neuromuscular transmission in these patients might have begun to improve even as early as one week after thymectomy and steadily improved by the end of one year of the study corresponding to clinical improvement.
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- * A study involving 22 patients post-thymectomy indicated significant long-term immunological changes, such as lymphopenia, reduced naive T cell counts, and low immunoglobulin levels, pointing to early immune aging.
- * Despite these changes, most patients still showed positive vaccine responses, but the findings suggest a need for preserving thymic tissue during surgery and increased monitoring for immune-related complications over time.
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