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Matrix implanted laser desorption ionization (MILDI) combined with ion mobility-mass spectrometry for bio-surface analysis. | LitMetric
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Matrix implanted laser desorption ionization (MILDI) combined with ion mobility-mass spectrometry for bio-surface analysis.

A Tempez M Ugarov T Egan J A Schultz A Novikov S Della-Negra Y Lebeyec M Pautrat M Caroff V S Smentkowski H-Y J Wang S N Jackson A S Woods

J Proteome Res

Ionwerks, Inc., 2472 Bolsover St., Suite 255, Houston, Texas 77005, USA.

Published: July 2005

The implantation of low velocity massive gold cluster ions allows homogeneous incorporation of a metallic matrix into the near-surface region of rat brain tissues. Subsequent analysis by laser desorption ionization mass spectrometry yields spectra exhibiting molecular ion peaks in the mass range up to 35 kDa similar to those observed by matrix-assisted LDI. Matrix-implanted LDI when combined with ion-mobility preseparation promises to be a useful technique for molecular imaging of biotissues with a laser microprobe.

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http://dx.doi.org/10.1021/pr0497879DOI Listing

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