Low potassium and magnesium status and decreased Na, K-pump activity is an endemic condition among rural Northeast Thais. The authors examined the effect of supplementing potassium and magnesium on erythrocyte potassium, sodium and magnesium content and on Na, K-pump activity. Rural Northeast Thai renal stone patients (62) were recruited, divided into four groups and supplemented for one month with potassium chloride (Group1, n = 16), potassium-sodium citrate (Group2, n = 15), chelated magnesium (Group 3, n =16) and potassium-magnesium citrate (Group 4, n =15) in order to achieve 40 mmol potassium, 10 mmol magnesium and 60 mmol citrate daily. After supplementation with potassium (Groups 1, 2 and 4), plasma potassium and Na, K-pump activity rose significantly in Groups 1, 2 and 4, but erythrocyte potassium rose only in Groups 2 and 4. When supplementing elemental magnesium (Groups 3 and 4), the chelated magnesium caused a significant increase in plasma potassium, erythrocyte potassium, sodium and magnesium without a significant increase in Na, K-pump activity. By contrast, potassium-magnesium citrate caused a significant increase in erythrocyte potassium and magnesium and Na, K-pump activity, but depressed erythrocyte sodium. These results suggest the forms of potassium and /or magnesium salts being supplemented should be considered because they affect erythrocyte potassium, sodium and magnesium content and Na, K-pump activity differently.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Exploring variances in meat quality between Qingyuan partridge chicken and Cobb broiler: Insights from combined multi-omics analysis.
Poult Sci
December 2024
State Key Laboratory of Livestock and Poultry Breeding, Guangdong Laboratory for Lingnan Modern Agriculture, College of Animal Science, South China Agricultural University, Guangzhou, PR China; Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, Key Laboratory of Chicken Genetics, Breeding and Reproduction, Ministry of Agriculture and Rural Affairs, Guangzhou, PR China. Electronic address:
Previously, animal breeding prioritized enhancing key economic traits to improve production efficiency, leading to a gradual difference in meat quality. However, the genetic factors influencing meat quality remain unclear. To identify key genetic pathways contributing to meat quality, native Chinese yellow-feathered chicken (Qingyuan Partridge Chicken, QPC; female, n=10), and commercial chicken broiler (Cobb broiler, CB; female, n=10) were used for meat quality assessment through metabolomics, proteomics, and phosphoproteomics sequencing.
View Article and Find Full Text PDFAcute oral digoxin in healthy adults hastens fatigue and increases plasma K during intense exercise, despite preserved skeletal muscle Na,K-ATPase.
J Physiol
December 2024
Institute for Health and Sport, Victoria University, Melbourne, Australia.
Article Synopsis
- - The study examined how the Na,K-ATPase inhibitor digoxin affects muscle content, potassium levels, and fatigue during intense exercise in healthy adults, using a double-blind crossover design with a placebo.
- - Results showed that while muscle Na,K-ATPase binding increased with digoxin treatment, muscle isoform levels did not change, suggesting a potential adaptation mechanism to maintain Na,K-ATPase function despite the drug's effects.
- - Exercise produced significant shifts in potassium levels, with digoxin leading to earlier fatigue and altered potassium responses compared to the placebo, highlighting digoxin's impact on muscle performance during high-intensity activities.
β3-adrenergic agonist counters oxidative stress and Na-K pump inhibitory S-glutathionylation of placental cells: implications for preeclampsia.
Am J Physiol Cell Physiol
January 2025
Cellular Membrane Biology Group, Kolling Medical Research Institute, University of Sydney, New South Wales, Australia.
Oxidative stress from placental ischemia/reperfusion and hypoxia/reoxygenation (H/R) in preeclampsia is accompanied by Na-K pump inhibition and S-glutathionylation of its β1 subunit (GSS-β1), a modification that inhibits the pump. β3-adrenergic receptor (β3-AR) agonists can reverse GSS-β1. We examined the effects of the agonist CL316,243 on GSS-β1 and sources of H/R-induced oxidative stress in immortalized first-trimester human trophoblast (HTR-8/SVneo) and freshly isolated placental explants from normal-term pregnancies.
View Article and Find Full Text PDFMultistability of bursting rhythms in a half-center oscillator and the protective effects of synaptic inhibition.
Front Cell Neurosci
September 2024
Neuroscience Institute, Georgia State University, Atlanta, GA, United States.
Article Synopsis
- * In leeches, the heartbeat is regulated by half-center oscillators (HCO) involving mutually inhibitory interneurons, and experiments reveal that changes in sodium/potassium pump current and hyperpolarization-activated current lead to distinct dysfunctional regimes or bursting activity.
- * New modeling findings show that a previously unrecognized bursting regime emerges alongside traditional patterns, offering higher spike frequencies for improved synaptic transmission, while the dynamics of neuromodulation can switch between these functional patterns depending on excitatory or inhibitory signals.
Reduction in mitochondrial ATP synthesis mimics the effect of low glucose in depolarizing neurons from the subpostremal nucleus of the solitary tract of rats.
J Bioenerg Biomembr
October 2024
Neurophysiology and Synapse Laboratory, Department of Physiology, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil.
Neurons of the subpostremal nucleus of the solitary tract (NTS) respond to changes in extracellular glucose with alterations in membrane potential with both depolarization and hyperpolarization. From 5 mM glucose, a rapid shift to 0.5 mM glucose produces a membrane depolarization by an unknown mechanism in most neurons.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!