Controlled normobaric interval hypoxytherapy and impulse low-intensity magnetic field application were proved to be the most promising methods that increase nonspecific resistance. Technical means to use those methods are specified.
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Biol Sport
January 2025
Institute of Sport Sciences, University of Lausanne, Lausanne, Switzerland.
Oxidative stress is augmented under hypoxic environments, which may be attenuated with antioxidant supplementation. We investigated the effects of dietary nitrate (NO-) supplementation combined with high-intensity training performed under hypoxic conditions on antioxidant/pro-oxidant balance. Thirty trained participants were assigned to one of three groups - HNO: hypoxia (13% FO) + NO-; HPL: hypoxia + placebo; CON: normoxia (20.
View Article and Find Full Text PDFJ Nucl Med
January 2025
Institute of Neuroscience and Medicine, Molecular Organization of the Brain (INM-2), Forschungszentrum Jülich, Jülich, Germany;
In animal studies it has been observed that the inhibitory neuromodulator adenosine is released into the cerebral interstitial space during hypoxic challenges. Adenosine's actions on the A adenosine receptor (AAR) protect the brain from oxygen deprivation and overexertion through adjustments in cerebral blood flow, metabolism, and electric activity. Using 8-cyclopentyl-3-(3-[F]fluoropropyl)-1-propylxanthine ([F]CPFPX), a PET tracer for the AAR, we tested the hypothesis that hypoxia-induced adenosine release reduces AAR availability in the human brain.
View Article and Find Full Text PDFPhysiol Behav
January 2025
Performance and Sport Rehabilitation Laboratory, Faculty of Sport Sciences, University of Castilla-La Mancha, Avda. Carlos III s/n., 45071, Toledo, Spain. Electronic address:
Normobaric hypoxia has become an innovative non-pharmacological therapy to treat cognitive dysfunction. Nevertheless, the acute effects of exposure to hypoxia on cognitive performance remain unclear. We aimed to determine the effects of different normobaric hypoxic exposures on cognitive function in healthy young adults.
View Article and Find Full Text PDFJ Physiol Biochem
November 2024
Graduate School of Health and Sports Science, Juntendo University, 1-1 Hirakagakuendai, Inzai, Chiba, 270-1695, Japan.
High-intensity intermittent training (HIIT) in a normobaric hypoxic environment enhances exercise capacity, possibly by increasing the mitochondrial content in skeletal muscle; however, the molecular mechanisms underlying these adaptations are not well understood. Therefore, we investigated whether HIIT under normobaric hypoxia can enhance the expression of proteins involved in mitochondrial biogenesis and dynamics in rat gastrocnemius muscle. Five-week-old male Wistar rats (n = 24) were randomly assigned to the following four groups: (1) sedentary under normoxia (20.
View Article and Find Full Text PDFMed Sci Sports Exerc
October 2024
Institute of Mountain Emergency Medicine, Eurac Research, Bolzano, ITALY.
Purpose: There is controversy whether there are meaningful physiological differences between hypobaric (HH) and normobaric hypoxia (NH). This study aimed to compare the cardiorespiratory responses to acute HH and NH under strictly controlled conditions. We hypothesized no differences at rest and during submaximal exercise, whereas during maximal exercise, a higher maximal ventilation (V̇Emax), peripheral oxygen saturation (SpO2) and maximal oxygen consumption (V̇O2max) in HH than in NH.
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