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Effectiveness of ozone nanobubble treatments on high biomass cyanobacterial blooms: A mesocosm experiment and field trial.
J Environ Manage
December 2024
Agriculture and Water Quality Education Center, Wright State University - Lake Campus, Celina, OH 45822, USA.
Cyanobacterial harmful algae blooms (cyanoHABs) are a global threat to water resources, and lake managers need effective strategies to suppress or control them. Algaecides may have negative environmental impacts, and their use is becoming restricted. Nanobubble ozone technology (NBOT) is an emerging water treatment option with potentially fewer negative impacts.
View Article and Find Full Text PDFCulturally responsive strategies and practical considerations for live tissue studies in Māori participant cohorts.
Front Res Metr Anal
November 2024
Department of Physiology, University of Otago, Dunedin, New Zealand.
Introduction: Indigenous communities globally are inequitably affected by non-communicable diseases such as cancer and coronary artery disease. Increased focus on personalized medicine approaches for the treatment of these diseases offers opportunities to improve the health of Indigenous people. Conversely, poorly implemented approaches pose increased risk of further exacerbating current inequities in health outcomes for Indigenous peoples.
View Article and Find Full Text PDFLarge-scale single-nuclei profiling identifies role for ATRNL1 in atrial fibrillation.
Nat Commun
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Cardiovascular Disease Initiative & Precision Cardiology Laboratory, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Atrial fibrillation (AF) is the most common sustained arrhythmia in humans, yet the molecular basis of AF remains incompletely understood. To determine the cell type-specific transcriptional changes underlying AF, we perform single-nucleus RNA-seq (snRNA-seq) on left atrial (LA) samples from patients with AF and controls. From more than 175,000 nuclei we find that only cardiomyocytes (CMs) and macrophages (MΦs) have a significant number of differentially expressed genes in patients with AF.
View Article and Find Full Text PDFOmission of etoposide in the treatment of haemophagocytic lymphohistiocytosis secondary to primary central nervous system lymphoma with satisfactory response.
BMJ Case Rep
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Department of Medicine, Division of Rheumatology, University of Florida, Gainesville, Florida, USA.
Haemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory condition that can be either familial or acquired and, if untreated, frequently results in multiorgan failure and death. Treatment of HLH typically requires a combination of glucocorticoids and cytotoxic chemotherapy. We describe the case of a woman who presented with signs and symptoms concerning for HLH who was later found to have a primary central nervous system (CNS) diffuse large B-cell lymphoma.
View Article and Find Full Text PDFIndirect and direct cannabinoid agonists differentially affect mesolimbic dopamine release and related behaviors.
Behav Neurosci
April 2024
Department of Psychology, The University of Memphis.
The cannabinoid system is being researched as a potential pharmaceutical target for a multitude of disorders. The present study examined the effect of indirect and direct cannabinoid agonists on mesolimbic dopamine release and related behaviors in C57BL/6J (B6) mice. The indirect cannabinoid agonist N-arachidonoyl serotonin (AA-5-HT) indirectly agonizes the cannabinoid system by preventing the metabolism of endocannabinoids through fatty acid amide hydrolase inhibition while also inhibiting transient receptor potential vanilloid Type 1 channels.
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