AI Article Synopsis
- Alcoholic liver disease (ALD) is prevalent in lower socio-economic groups and is exacerbated by heavy drinking and nutritional deficiencies, leading to oxidative stress in the liver due to ethanol.
- Serum malondialdehyde (MDA) levels, indicating oxidative stress, rise with disease severity, while levels of antioxidant vitamins E and C are lower in ALD patients compared to healthy individuals.
- The results suggest that liver damage could result from higher demands or depletion of antioxidants due to alcohol consumption.
Article Abstract
Background: [corrected] Alcoholic liver diseases (ALD) are very common in lower socio-economical strata due to heavy drinking habits and multiple nutritional deficiencies. Ethanol causes liver damage by many mechanisms. The generation of lipid peroxidation by free radicals has been proposed as a mechanism for ethanol induced hepatotoxicity. These free radicals are destroyed by anti-oxidants. Many anti-oxidants are present in the diet, e.g., vitamin E, vitamin C etc. However, poor nutrition or malabsorption leads to deficiency of these vitamins. This may impair the anti-oxidative defense leading to ethanol induced oxidative stress and then to liver damage.
Methods: Oxidative stress and antioxidant defense were assessed in patients with alcoholic liver disease. Serum malondialdehyde (MDA) concentrations were measured as an index of lipid peroxidation, i.e., oxidative stress; and serum vitamins E and C concentrations were measured as an index of antioxidant status.
Results: Serum MDA concentrations were increased with the increase in severity of the disease. Concentrations of serum vitamins E and C were decreased in patients with alcoholic liver disease as compared to controls.
Conclusions: Our observations may be due to increased demands of the same or increased utilization.
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| http://dx.doi.org/10.1016/j.cccn.2004.12.012 | DOI Listing |
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