The authors evaluated data on the extent of the problem of tuberculosis and the effectiveness of control measures in the surveillance of TB in the Czech Republic (CR) in 1990. The data are assembled and monitored by the same method for a period of 10 years. The incidence of respiratory TB confirmed bacteriologically was 11.3/100,000 population, incl. 5.7/100,000 already direct smear positive cases. Since 1988 the incidence did not change, in 1990 it increased slightly. The mortality from TB remained low. A total of 0.8/100,000 patients died, mostly old people not treated for TB before death. The so-called risk factors which may have participated in the development of TB were analyzed. Two thirds of the patients were men. For advanced TB was more frequent in young and middle-aged men, while in old men less advanced TB, positive only on cultivation, predominated. In women the majority of patients was older than 65 years. As to risk factors in young patients lack of cooperation was proved, e. g. alcohol abuse in two thirds amount of other serious diseases. Treatment of TB patients was successful in 96%. Causes of therapeutic failures were lack of cooperation and complications of antituberculotic treatment. In-patient treatment lasted on average three months, treatment with antituberculotics a total of 9 months. In 1990 TB in the CR was supervised, the epidemiological situation was favourable and comparable with advanced European countries. TB remains, however, a serious health problem in the CR. It is important to define, screen and ensure intensive supervision of subjects with various so-called risk factors.
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Med Oral Patol Oral Cir Bucal
January 2025
Hospital Universitario "Dr. José Eleuterio González" Av. Dr. José Eleuterio González 235, Mitras Centro 64460 Monterrey, Mexico
Background: Craniofacial mucormycosis is a highly lethal infectious disease. This study aims to assess and analyze multiple variables, including clinical, socioeconomic, and biochemical markers, to identify and examine risk factors for mortality associated with this mycotic infection.
Material And Methods: A retrospective analysis was conducted on 38 patients who sought medical attention at the Otolaryngology and Head and Neck Surgery Division of a tertiary-level hospital in Monterrey, Mexico.
Age Ageing
January 2025
Aging Research Center, Department Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.
Objective: We aimed to investigate the association of sociodemographic, clinical and functional characteristics with the volume of transitions and specific trajectories across living and care settings.
Methods: Using data from the Swedish National Study on Aging and Care in Kungsholmen study, we identified transitions across home (with or without social care), nursing homes, hospitals and postacute care facilities among 3021 adults aged 60+. Poisson and multistate models were used to investigate the association between sociodemographic, clinical and functional characteristics and both the overall volume and hazard ratios (HRs) of specific transitions.
Cardiovasc Toxicol
January 2025
Department of Cadre Ward, The First Affiliated Hospital of Harbin Medical University, No. 23, Postal Street, Harbin, 150001, Heilongjiang, PR China.
Atherosclerosis risk is elevated in diabetic patients, but the underlying mechanism such as the involvement of macrophages remains unclear. Here, we investigated the underlying mechanism related to the pro-inflammatory activation of macrophages in the development of diabetic atherosclerosis. Bioinformatics tools were used to analyze the macrophage-related transcriptome differences in patients with atherosclerosis and diabetic mice.
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January 2025
Forestry and Forest Products Research Institute, Matsunosato 1, Tsukuba, Ibaraki, 305-8687, Japan.
Anthropogenic disturbances degrade ecosystems, elevating the risk of emerging infectious diseases from wildlife. However, the key environmental factors for preventing tick-borne disease infection in relation to host species, landscape components, and climate conditions remain unknown. This study focuses on identifying crucial environmental factors contributing to the outbreak of severe fever with thrombocytopenia syndrome (SFTS), a tick-borne disease, in Miyazaki Prefecture, southern Japan.
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