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Relationships between genetic polymorphisms of IL-1β and rheumatoid arthritis.
Cell Mol Biol (Noisy-le-grand)
January 2025
Technical Institute of Al-Diwaniyah, Al-Furat Al-Awsat Technical University (ATU), Iraq.
This study aimed to investigate the association between the interleukin-1 beta (IL-1β) gene polymorphism (rs2853550) and the risk of rheumatoid arthritis (RA) in a sample of the Iraqi population. The study included 100 RA patients and 100 healthy controls. Demographic characteristics, including age and gender, were collected and compared between the two groups.
View Article and Find Full Text PDFEffects of dioscin from Dioscorea nipponica on TL1A/DR3 and Th9 cells in a collagen-induced arthritis mouse model.
Int Immunopharmacol
January 2025
Department of Anatomy, Basic Medical Institute, Chengde Medical University, Chengde 067000 Hebei, China. Electronic address:
Rheumatoid arthritis (RA) is a systemic autoimmune disease, and TL1A and its receptor DR3 play important roles in its pathogenesis. Th9 cells are involved in RA development. Dioscin from Dioscorea nipponica (DDN) has a therapeutic effect on RA, but its effect on TL1A/DR3 and Th9 cells remains unclear.
View Article and Find Full Text PDFSLC7A11 suppresses pyroptosis to alleviate rheumatoid arthritis development by modulating the IL-17 pathway.
Int Immunopharmacol
January 2025
Background: Rheumatoid arthritis (RA) is an autoimmune disease of unknown etiology. This study aims to explore the potential mechanisms by which solute carrier family 7 member 11 (SLC7A11) influences RA development.
Methods: Collagen-induced arthritis (CIA) mice were constructed to observe disease onset and pathological scores.
Poor Prognostic Factors and Unmet Needs in Rheumatoid Arthritis.
Rheumatology (Oxford)
January 2025
Medical University of Vienna, Division of Rheumatology, Department of Medicine 3, Medical University of Vienna, Spitalgasse 23, Vienna, 1090, Austria.
Prognostic factors in rheumatoid arthritis relate to several aspects, such as prediction of joint damage and loss of function or prediction of response to a particular therapy. Since many decades, it is well established that high disease activity, especially exemplified by swollen joint counts and acute phase reactants, is associated with progression of joint damage. In addition, rheumatoid factor (RF) positive patients, but not patients with anti-citrullinated peptide antibodies (ACPA) are particularly prone to high disease activity and joint destruction.
View Article and Find Full Text PDFEthnicity-specific patterns of epigenetic age acceleration in rheumatoid arthritis.
Geroscience
January 2025
Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.
Rheumatoid arthritis (RA) is an age-related chronic inflammatory disease which may include accelerated biological ageing processes in its pathogenesis. To determine if increased biological age is associated with risk of RA and/or is present once disease is established. We used DNA methylation to compare biological age (epigenetic age) of immune cells in adults at risk of RA and those with confirmed RA, including twins discordant for RA.
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