Background: We previously derived a whole-body resting energy expenditure (REE) prediction model by using organ and tissue mass measured by magnetic resonance imaging combined with assumed stable, specific resting metabolic rates of individual organs and tissues. Although the model predicted REE well in young persons, it overpredicted REE by approximately 11% in elderly adults. This overprediction may occur because of a decline in the fraction of organs and tissues as cell mass with aging.
Objective: The aim of the present study was to develop a cellular-level REE prediction model that would be applicable across the adult age span. Specifically, we tested the hypothesis that REE can be predicted from a combination of organ and tissue mass, the specific resting metabolic rates of individual organs and tissues, and the cellular fraction of fat-free mass.
Design: Fifty-four healthy subjects aged 23-88 y had REE, organ and tissue mass, body cell mass, and fat-free mass measured by indirect calorimetry, magnetic resonance imaging, whole-body (40)K counting, and dual-energy X-ray absoptiometry, respectively.
Results: REE predicted by the cellular-level model was highly correlated with measured REE (r = 0.92, P < 0.001). The mean difference between measured REE (x+/- SD: 1487 +/- 294 kcal/d) and predicted REE (1501 +/- 300 kcal/d) for the whole group was not significant, and the difference between predicted and measured REE was not associated with age (r = 0.009, NS).
Conclusion: The present approach establishes an REE-body composition link with the use of a model at the cellular level. The combination of 2 aging-related factors (ie, decline in both the mass and the cellular fraction of organs and tissues) may account for the lower REE observed in elderly adults.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1093/ajcn/81.4.799 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Bioprinted optoelectronically active cardiac tissues.
Sci Adv
January 2025
Department of Electrical and Computer Engineering, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA.
Electrical stimulation of existing three-dimensional bioprinted tissues to alter tissue activities is typically associated with wired delivery, invasive electrode placement, and potential cell damage, minimizing its efficacy in cardiac modulation. Here, we report an optoelectronically active scaffold based on printed gelatin methacryloyl embedded with micro-solar cells, seeded with cardiomyocytes to form light-stimulable tissues. This enables untethered, noninvasive, and damage-free optoelectronic stimulation-induced modulation of cardiac beating behaviors without needing wires or genetic modifications to the tissue solely with light.
View Article and Find Full Text PDFTrace elements in fish species from the Punjnad headworks: Bioaccumulation and human health risk assessment.
PLoS One
January 2025
Department of Entomology, Faculty of Agriculture and Environment, The Islamia University of Bahawalpur, Bahawalpur, Pakistan.
Aquatic toxicology, as a result of industrial and agrieqcultural effluences, has become a global concern impacting not only the well-being of aquatic organisms but human health as well. The current study evaluated the impact of four toxic trace elements (TTEs) Cadmium (Cd), copper (Cu), lead (Pb), and nickel (Ni) in three organs (liver, gills, and muscles) of five fish species viz, Rita rita, Sperata sarwari, Wallago attu, Mastacembelus armatus, and Cirrhinus mrigala collected from right and left banks of Punjnad headworks during winter, spring, and summer. We investigated the accumulation (mg/kg) of these TTEs in fish in addition to the human health risk assessment.
View Article and Find Full Text PDFRspo3-mediated metabolic liver zonation regulates systemic glucose metabolism and body mass in mice.
PLoS Biol
January 2025
Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan.
The unique architecture of the liver consists of hepatic lobules, dividing the hepatic features of metabolism into 2 distinct zones, namely the pericentral and periportal zones, the spatial characteristics of which are broadly defined as metabolic zonation. R-spondin3 (Rspo3), a bioactive protein promoting the Wnt signaling pathway, regulates metabolic features especially around hepatic central veins. However, the functional impact of hepatic metabolic zonation, regulated by the Rspo3/Wnt signaling pathway, on whole-body metabolism homeostasis remains poorly understood.
View Article and Find Full Text PDFTumor localization strategies of multi-cancer early detection tests: a quantitative assessment.
JNCI Cancer Spectr
January 2025
Exact Sciences Corporation, Madison, WI, United States.
Background: Multi-cancer early detection (MCED) tests may expand cancer screening. Characterizing diagnostic resolution approaches following positive MCED tests is critical. Two trials employed distinct resolution approaches: a molecular signal to predict tissue of origin (TOO) and an imaging-based diagnostic strategy.
View Article and Find Full Text PDFBuffExDb: web-based tissue-specific gene expression resource for breeding and conservation programmes in Bubalus bubalis.
Database (Oxford)
January 2025
Division of Agricultural Bioinformatics, ICAR-Indian Agricultural Statistics Research Institute, Library Avenue, PUSA, New Delhi 110012, India.
Amidst the global challenge of extreme poverty, the livestock sector can significantly contribute to global sustainable development goals by enhancing resilience, smallholder productivity, and market participation. The Indian livestock sector is one of the largest in the world with a total livestock population of 535.82 million, ∼10.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!