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| http://dx.doi.org/10.1128/JCM.43.4.2024-2025.2005 | DOI Listing |
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An Unexpected Case of Generalized Tetanus.
Cureus
December 2024
Intensive Care Unit, Unidade Local de Saúde da Região de Aveiro, Aveiro, PRT.
Tetanus is a disease of the nervous system caused by a toxin produced by , an anaerobe found in high concentrations in the soil. The occurrence of tetanus is related to contaminated traumatic wounds, and most patients have had some failure in their immunization. However, there are rare case reports of generalized tetanus in patients with proper vaccination schemes who failed to receive appropriate prophylaxis after high-risk exposure.
View Article and Find Full Text PDFTetanus Vaccination in Agricultural Workers: A Retrospective Study on Seroprevalence over 10 Years.
Vaccines (Basel)
December 2024
Department of Health Promotion Sciences Maternal and Child Care, Internal Medicine and Medical Specialties 'Giuseppe D'Alessandro', University of Palermo, 90127 Palermo, Italy.
Background/objectives: Tetanus is a serious, non-contagious infection caused by , which remains a global health threat despite the availability of an effective vaccine. The current state of immunization for agricultural workers in Italy reveals significant disparities, reflecting a non-homogeneous distribution of vaccination coverage across regions and subgroups. The aim of the study was to investigate the prevalence of tetanus antibodies in a cohort of agricultural workers in Eastern Sicily in order to evaluate possible public health strategies for improving vaccination coverage.
View Article and Find Full Text PDFExpression of Recombinant Clostridial Neurotoxin by .
Microorganisms
December 2024
Department of Bacteriology, University of Wisconsin-Madison, Madison, WI 53706, USA.
Tetanus neurotoxins (TeNT) and botulinum neurotoxins (BoNTs) are closely related ~150 kDa protein toxins that together comprise the group of clostridial neurotoxins (CNTs) expressed by various species of . While TeNT is expressed as a single polypeptide, BoNTs are always produced alongside multiple non-toxic proteins that form a stabilizing complex with BoNT and are encoded in a conserved toxin gene cluster. It is unknown how evolved without a similar gene cluster and why complex-free TeNT is secreted as a stable and soluble protein by , whereas complexing proteins appear to be essential for BoNT stability in culture supernatants of .
View Article and Find Full Text PDFAnti-Tetanus Vaccination Is Associated with Reduced Occurrence and Slower Progression of Parkinson's Disease-A Retrospective Study.
Biomedicines
November 2024
Brain Institute, Tel-Aviv Sourasky Medical Center, Faculty of Medical & Health Sciences, Sagol School of Neurosciences, Tel Aviv University, Tel-Aviv 6997801, Israel.
Parkinson's disease (PD) is a neurodegenerative disorder that progressively damages the autonomic and central nervous systems, leading to hallmark symptoms such as resting tremor, bradykinesia, and rigidity. Despite extensive research, the underlying cause of PD remains unclear, and current treatments are unable to halt the progression of the disease. In this retrospective study, based on historical electronic health records (EHR) from a national health provider covering the period from 2003 to 2023, we investigated the impact of vaccination and medication purchases on PD occurrence and severity.
View Article and Find Full Text PDFRevitalizing tetanus vaccine literacy post road accidents: a comprehensive examination of knowledge and awareness initiative among non-medical university students in Lahore, Pakistan.
Front Immunol
January 2025
Institute of Pharmaceutical Sciences, University of Veterinary and Animal Sciences, Lahore, Punjab, Pakistan.
Introduction: Tetanus, caused by , poses a life-threatening risk by affecting the nervous system and inducing muscle tightness. The objective of this study is to examine the knowledge, attitudes, and behaviors of non-medical university students regarding the tetanus vaccine in the context of post-road accidents.
Methods: A descriptive cross-sectional study was conducted in 2023, involving 378 students from non-medical disciplines, primarily from information technology, business administration, and engineering faculties, with a mean age of 20.
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