AI Article Synopsis
- A TaqMan-minor groove binding assay was developed to identify a specific nonsense mutation in the plcR gene of Bacillus anthracis and its related species.
- The assay successfully distinguished B. anthracis from B. cereus and B. thuringiensis isolates.
- It revealed that the nonsense mutation is widely present in 89 diverse and global strains of B. anthracis.
Article Abstract
A TaqMan-minor groove binding assay designed around a nonsense mutation in the plcR gene was used to genotype Bacillus anthracis, B. cereus, and B. thuringiensis isolates. The assay differentiated B. anthracis from these genetic near-neighbors and determined that the nonsense mutation is ubiquitous across 89 globally and genetically diverse B. anthracis strains.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1081367 | PMC |
| http://dx.doi.org/10.1128/JCM.43.4.1995-1997.2005 | DOI Listing |
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