Objective: To study the antioxidation of fraction F and H isolated from Naja naja atra venom on homogenate and RBC autoxidation. And to explore the effect of two fractions on the activities of antioxidation enzymes in mice.
Method: Samples of tissues homogenates and RBC suspension were pretreated with fraction F/H, and then their generation of malondialdehyde(MDA) was examined. The effects of fraction F/H on O2-* produced by pyrogallol autoxidation and *OH produced by Cu2+ -VitC were checked. After being administrated i.p. with fraction F/H for 15 days, superoxide dismutase and hydroperoxidase in mice were measured for their activities.
Result: Fraction F/H inhibited RBC autohemolysis and the generation of MDA decreased. The production of lipid peroxides in normal brain, liver and heart homogenate of rat and the elevation of lipid peroxides induced by cysteine and FeSO4 in homogenate were inhibited by addition of fraction F/H. The O2-* produced by autoxidation of pyrogallol and the *OH produced by Cu2+ -VitC system could be scavenged by fraction F/H (the potency of scavenging oxygen free radical is that fraction H > fraction F). Fraction F/H all increased the activities of several antioxidation enzymes in mice to different extents.
Conclusion: Fraction F/H have the effect of antilipid peroxidation,may scavenge active oxygen free radical and increase the activity of SOD.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Unraveling the Phase Behavior and Stability of Surfactant-Free Microemulsions: From Molecular Interactions to Macroscopic Properties.
Langmuir
December 2024
New Cornerstone Science Laboratory, Center for Combustion Energy, Key Laboratory for Thermal Science and Power Engineering of Ministry of Education, Department of Energy and Power Engineering, Tsinghua University, Beijing 100084, China.
Article Synopsis
- This study explores surfactant-free microemulsions (SFMEs) and their formation in water/ethanol/oil systems, revealing their unique properties and diverse applications in enzyme reactions and nanoparticle synthesis.! -
- Using experimental methods, molecular dynamics simulations, and Flory-Huggins theory, the research delves into the mechanisms of nucleation and stabilization in SFMEs, uncovering the formation of nanostructures at both ∼1 nm and ∼100 nm scales.! -
- The findings emphasize the balance of mixing entropy and internal energy in stabilizing nanodroplets, suggesting that manipulating component ratios can optimize stability and enhance the industrial use of these materials.!
Delocalization error poisons the density-functional many-body expansion.
Chem Sci
December 2024
Department of Chemistry & Biochemistry, The Ohio State University 151 W. Woodruff Ave. Columbus Ohio 43210 USA
The many-body expansion is a fragment-based approach to large-scale quantum chemistry that partitions a single monolithic calculation into manageable subsystems. This technique is increasingly being used as a basis for fitting classical force fields to electronic structure data, especially for water and aqueous ions, and for machine learning. Here, we show that the many-body expansion based on semilocal density functional theory affords wild oscillations and runaway error accumulation for ion-water interactions, typified by F(HO) with ≳ 15.
View Article and Find Full Text PDFDiagnostic Accuracy of CT for the Detection of Hepatic Steatosis: A Systematic Review and Meta-Analysis.
Radiology
November 2024
From the Department of Radiology, Northwestern University Feinberg School of Medicine, 676 N St. Clair St, Arkes Family Pavilion, Ste 800, Chicago, IL 60611 (M.H., D.A., S.T., F.H.M., A.A.B.); and Department of Diagnostic Imaging, St. Jude Children's Research Hospital, Memphis, Tenn (A.D.S.).
Background CT plays an important role in the opportunistic identification of hepatic steatosis. CT performance for steatosis detection has been inconsistent across various studies, and no clear guidelines on optimum thresholds have been established. Purpose To conduct a systematic review and meta-analysis to assess CT diagnostic accuracy in hepatic steatosis detection and to determine reliable cutoffs for the commonly mentioned measures in the literature.
View Article and Find Full Text PDFExploring the Bioactive Potential of F.H. Wigg Aerial Parts on MDA Breast Cancer Cells: Insights into Phytochemical Composition, Antioxidant Efficacy, and Gelatinase Inhibition within 3D Cellular Models.
Plants (Basel)
October 2024
Department of Chemistry and Technologies of Drug, Sapienza University, Piazzale Aldo Moro 5, 00185 Rome, Italy.
In this work, aerial parts of F.H. Wigg.
View Article and Find Full Text PDFTissue-Based Predictors of Impaired Right Ventricular Strain in Coronary Artery Disease: A Multicenter Stress Perfusion Study.
Circ Cardiovasc Imaging
August 2024
Division of Cardiology, Columbia University Irving Medical Center, New York (J.K.).
Background: Right ventricular (RV) dysfunction is known to impact prognosis, but its determinants in coronary artery disease are poorly understood. Stress cardiac magnetic resonance (CMR) has been used to assess ischemia and infarction in relation to the left ventricle (LV); the impact of myocardial tissue properties on RV function is unknown.
Methods: Vasodilator stress CMR was performed in patients with known coronary artery disease at 7 sites between May 2005 and October 2018.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!