A series of novel ligands for the glucocorticoid receptor containing two heterocycles were synthesized. These compounds were investigated for a dissociative profile using transrepression and transactivation assays. Several compounds were tested in vivo and showed the ability to reduce inflammation in a mouse.
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| http://dx.doi.org/10.1016/j.bmcl.2005.02.009 | DOI Listing |
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