A short, stereoselective, and a common approach for the synthesis of 4,5-disubstituted delta-lactones simplactone B and its analogue using Evans protocol is described.
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http://dx.doi.org/10.1016/j.bmcl.2005.02.059 | DOI Listing |
In this review we have compiled multicomponent reactions (MCRs) that produce cyclic structures. We have covered articles reported since 2019 to showcase the recent advances in this area. In contrast to other available reviews on this topic, we focus specifically on MCRs with strong prospects in medicinal chemistry.
View Article and Find Full Text PDFMolecules
November 2024
Collaborative Innovation Center for Efficient Utilization of Water Resources, North China University of Water Resources and Electric Power, Zhengzhou 450046, China.
Ionic liquids have been utilized in numerous significant applications within the field of chemistry, particularly in organic chemistry, due to their unique physical and chemical properties. In the realm of asymmetric transition-metal-catalyzed transformations, chiral ionic-liquid-supported ligands and their corresponding transition-metal complexes have facilitated these processes in unconventional solvents, especially ionic liquids and water. These innovative reaction systems enable the recycling of transition-metal catalysts while producing optically active organic molecules with comparable or even higher levels of chemo-, regio-, and stereoselectivity compared to their parent catalysts.
View Article and Find Full Text PDFJ Org Chem
December 2024
School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland 4072, Australia.
l-Guluronic acid is integral to the structures of alginates and to the pathogenesis of . The exploitation of this hexose in both existing and new contexts is, however, limited by its prohibitively high commercial cost. We report on a short and efficient synthetic route to an l-GulA building block from a simple d-mannose thioglycoside.
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October 2024
Faculty of Food Technology and Biotechnology, University of Zagreb, Zagreb, Croatia.
Introduction: Deep eutectic solvents (DESs) have emerged as green solvents with versatile applications, demonstrating significant potential in biocatalysis. They often increase the solubility of poorly water-soluble substrates, serve as smart co-substrates, modulate enzyme stereoselectivity, and potentially improve enzyme activity and stability. Despite these advantages, screening for an optimal DES and determining the appropriate water content for a given biocatalytic reaction remains a complex and time-consuming process, posing a significant challenge.
View Article and Find Full Text PDFChemistry
November 2024
Department of Chemistry, Yale University, New Haven, 06520, Connecticut, USA.
Sialic acids are monosaccharide residues involved in several biological processes. Controlling the stereoselectivity of sialylation reactions is challenging and mechanistic studies on the structure of its intermediate, the sialyl cation, are scarce. Here it is shown that a sialyl cation can be generated and isolated from an ionized sialic acid precursor.
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