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A pre-vertebrate endodermal origin of calcitonin-producing neuroendocrine cells.
Development
October 2024
Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK.
Vertebrate calcitonin-producing cells (C-cells) are neuroendocrine cells that secrete the small peptide hormone calcitonin in response to elevated blood calcium levels. Whereas mouse C-cells reside within the thyroid gland and derive from pharyngeal endoderm, avian C-cells are located within ultimobranchial glands and have been reported to derive from the neural crest. We use a comparative cell lineage tracing approach in a range of vertebrate model systems to resolve the ancestral embryonic origin of vertebrate C-cells.
View Article and Find Full Text PDFUltimobranchial body cyst in an adult horse: clinical, histopathologic, and immunohistochemical features.
J Vet Diagn Invest
January 2024
Departamento de Clínica Médica, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, São Paulo, Brazil.
A 9-y-old Mangalarga Marchador gelding was referred to a veterinary hospital because of a swelling on the upper right side of the neck. Ultrasound examination revealed a multilocular structure adjacent to the thyroid gland with low echogenic content suggestive of fluid. The mass was removed surgically.
View Article and Find Full Text PDFCribriform Morular Thyroid Carcinoma - Ultimobranchial Pouch-Related? Deep Molecular Insights of a Unique Case.
Endocr Pathol
September 2023
Thyroid Center LUKS, Lucerne, Switzerland.
A 44-year-old female patient with a familial adenomatous polyposis (FAP) was diagnosed with a cribriform morular thyroid carcinoma (CMTC). We observed within the very necrotic tumor a small but distinct poorly differentiated carcinomatous component. As expected, next generation sequencing of both components revealed a homozygous APC mutation and in addition, a TERT promoter mutation.
View Article and Find Full Text PDFC-cell differentiation in the wall of an aberrant ultimobranchial sinus in the thyroid gland of an old rat.
Vet Med Sci
March 2023
Departamento de Citología e Histología Normal y Patológica, Facultad de Medicina, Universidad de Sevilla, Sevilla, Andalucía, Spain.
Background: In mammals, the thyroid gland possesses two types of endocrine cells, follicular cells and C cells, which have different functions but share a similar endodermal origin (although from different regions of the primitive pharynx). Specifically, follicular cells derive from the ventral pharyngeal floor, while C cells derive from the fourth pair of pharyngeal pouches through the ultimobranchial bodies (UBBs). Disruptions to human midline thyroid morphogenesis are relatively frequent and known as thyroid dysgenesis, which is the leading cause of congenital hypothyroidism.
View Article and Find Full Text PDFMorphological, histological and ultra-structural studies on the ultimobranchial body of goat (Capra hircus).
Anat Histol Embryol
May 2022
Faculty of Veterinary Medicine, Department of Histology and Cytology, Zagazig University, Zagazig, Egypt.
Ultimobranchial body (UBB) remnant was considered as an enigma till the last few years, then it was recognized as a necessary organ where it is the origin of the parafollicular cells. The samples were fixed and processed for the histological and electron microscopic examination. Macroscopically, the UBB remnant appeared as a white mass at the end of the cranial one-third of the thyroid lobe.
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