Aim: To study the status of the stomach, duodenum and biliary tracts in young patients with chronic hepatitis C.
Material And Methods: We studied associated pathology of the gastroduodenal zone and biliary tract in 140 patients with CHC aged 16 to 35 years (mean age 25 +/- 0.8 years). We used USI and MRT of the abdominal organs, fibroesophagogastroduodenoscopy with biopsy of gastric mucosa for H. pylori, fractional duodenal tubing. 30 healthy males were controls.
Results: Asymtomatic gastroduodenal and biliary defects were found (75.5%). Endoscopic signs of gastroduodenal lesions were frequent (76.3%) in CHC patients, the majority of them were associated with H. Pylori and were not significantly different from those in the controls. Biliary tracts pathology, as shown by USI and MRT, occurred in 50.8%, were primarily functional (74.5%) and combined with high occurrence of bile mixed microflora with predominance of B. Fragilis (81%). Correlation of pathological changes of the gastroduodenal zone and biliary tract was established in CHC patients. How ever, they do not correlate with clinicolaboratory and histological signs of HCV infection. CONCLUSION. Young patients with CHC demonstrated no correlation between pathological changes of the gastroduodenal zone, biliary tracts and clinicolaboratory, histological signs of HCV infection. Therefore, it is recommended not to eradicate HP-infection and not to suppress opportunistic bile microflora in CHC young patients in the absence of clinical symptoms of gastrointestinal changes.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
An analysis of the global burden of gallbladder and biliary tract cancer attributable to high BMI in 204 countries and territories: 1990-2021.
Front Nutr
December 2024
Department of Clinical Laboratory, The Fifth Affiliated Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Background: Gallbladder and biliary tract cancers (GBTCs) are aggressive with poor prognosis, often undetected until advanced stages. High Body Mass Index (BMI) is a significant risk factor, contributing substantially to GBTC mortality and Disability-Adjusted Life Years (DALYs). This study aimed to quantify the global burdens of GBTCs attributable to high BMI from 1990 to 2021, thereby developing more rational prevention and treatment strategies for GBTC.
View Article and Find Full Text PDFDigestive cancers: mechanisms, therapeutics and management.
Signal Transduct Target Ther
January 2025
Department of Medicine II, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Cancers of the digestive system are major contributors to global cancer-associated morbidity and mortality, accounting for 35% of annual cases of cancer deaths. The etiologies, molecular features, and therapeutic management of these cancer entities are highly heterogeneous and complex. Over the last decade, genomic and functional studies have provided unprecedented insights into the biology of digestive cancers, identifying genetic drivers of tumor progression and key interaction points of tumor cells with the immune system.
View Article and Find Full Text PDFThe role of fluorescent cholangiography to improve operative safety in different severity degrees of acute cholecystitis during emergency laparoscopic cholecystectomy: a prospective cohort study.
Int J Surg
December 2024
Department of Surgery, Azienda Unità Sanitaria Locale Ferrara, University of Ferrara, Via Valle Oppio, Lagosanto, Ferrara, Italy.
Background: Currently, there is limited scientific evidence regarding the effectiveness of fluorescent cholangiography in emergency cholecystectomy for acute cholecystitis. The primary aim of this study was to assess the efficacy of near-infrared fluorescent cholangiography (NIRF-C) in different severity degrees of acute cholecystitis.
Materials And Methods: Inclusion criteria were patients with a clinical and radiological (abdominal ultrasound and/or computed tomography) diagnosis of acute cholecystitis based on the revised 2018 Tokyo guidelines who underwent laparoscopic cholecystectomy within 24-72 h from the onset of symptoms and patients with ASA score of 0-3.
Short- and long-term outcomes following laparoscopic liver resection for hepatocellular carcinoma combined with type I/II portal vein tumor thrombus.
Updates Surg
January 2025
Division of Liver Surgery, Department of General Surgery, West China Hospital, Sichuan University, 37 Guo Xue Road, Wu hou District, Chengdu, 610041, China.
Background: Despite the expanding indications for laparoscopic liver resection (LLR), its role in hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT) remains unclear. The aim of the current study is to compare the short- and long-term outcomes following LLR and open liver resection (OLR) for HCC with PVTT.
Methods: All HCC patients with PVTT registered for surgery between April 2015 and May 2022 were enrolled.
Ramadan intermittent fasting for patients with gastrointestinal and hepatobiliary diseases: practical guidance for health-care professionals.
Lancet Gastroenterol Hepatol
February 2025
Digestive Diseases Unit, Kettering General Hospital, University Hospital of Northamptonshire NHS Group, Kettering, UK; Department of Population Health Sciences, College of Life Sciences, University of Leicester, Leicester, UK.
Ramadan intermittent fasting can pose challenges and risks for some groups of patients. Based on a narrative literature review and our clinical expertise, we provide practical guidance for clinicians managing patients with gastrointestinal and hepatobiliary conditions who wish to fast during Ramadan. Following the established International Diabetes Federation and Diabetes and Ramadan International Alliance risk stratification framework, we categorised patients' risk as low or moderate, high, or very high.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!