Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/00005176-200504001-00026 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Tim-1-mediated extracellular matrix promotes the development of hepatocellular carcinoma.
Acta Biochim Biophys Sin (Shanghai)
October 2024
Department of General Surgery, the First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Tim-1 (T-cell immunoglobulin and mucin domain 1), also known as Kim-1 (kidney injury molecule 1) or hepatitis A virus cellular receptor 1 (HAVCR1), is a transmembrane protein expressed on various immune and epithelial cells. It plays a role in modulating inflammatory and immune responses. In this study, we find that Tim-1 is overexpressed in hepatocellular carcinoma (HCC) samples and that its expression is significantly correlated with postoperative survival.
View Article and Find Full Text PDFSTUDY THE RELATIONSHIP BETWEEN OSTEOPROTEGERIN AND KIDNEY INJURY MOLECULE-1 AND SOME BIOCHEMICAL VARIABLES IN PATIENTS WITH KIDNEY STONES.
Georgian Med News
October 2024
2College of Medicine, University of Tikrit, Saladin, Iraq.
Kidney stones are a common disorder that affects men and women. Stones are hard, abnormal deposits that form inside the kidneys. They are also known as kidney stones or urinary stones.
View Article and Find Full Text PDFThe Role of TIM-1 and CD300a in Zika Virus Infection Investigated with Cell-Based Electrical Impedance.
Biosensors (Basel)
July 2024
Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, KU Leuven, 3000 Leuven, Belgium.
Orthoflaviviruses cause a major threat to global public health, and no antiviral treatment is available yet. Zika virus (ZIKV) entry, together with many other viruses, is known to be enhanced by phosphatidylserine (PS) receptors such as T-cell immunoglobulin mucin domain protein 1 (TIM-1). In this study, we demonstrate for the first time, using cell-based electrical impedance (CEI) biosensing, that ZIKV entry is also enhanced by expression of CD300a, another PS receptor.
View Article and Find Full Text PDFChikungunya virus release is reduced by TIM-1 receptors through binding of envelope phosphatidylserine.
J Virol
August 2024
Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, Georgia, USA.
Unlabelled: T-cell immunoglobin and mucin domain protein-1 (TIM-1) mediates entry of chikungunya virus (CHIKV) into some mammalian cells through the interaction with envelope phospholipids. While this interaction enhances entry, TIM-1 has been shown to tether newly formed HIV and Ebola virus particles, limiting their efficient release. In this study, we investigate the ability of surface receptors such as TIM-1 to sequester newly budded virions on the surface of infected cells.
View Article and Find Full Text PDFInhibition of the TIM-1 and -3 signaling pathway ameliorates disease in a murine model of rheumatoid arthritis.
Clin Exp Immunol
September 2024
Department of Hematology and Rheumatology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka, Japan.
Members of the T-cell immunoglobulin and mucin (TIM) family, which is crucial for T-cell function, are implicated in autoimmunity. TIM-1 and -3 play distinct roles in autoimmunity, with TIM-1 acting as a costimulatory molecule and TIM-3 regulating Th1 responses. We investigated the therapeutic potential of anti-TIM-1 (RMT1-10) and anti-TIM-3 (RMT3-23) antibodies in an autoimmune arthritis model.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!