Acute toxicity (LC50) of fenvalerate at 96 h to the freshwater fish Cirrhinus mrigala was 6 microg/L. The accumulation of fenvalerate at different exposure periods (1, 2, 3, 4 d) on different tissues, namely gill, muscle, and liver, was first confirmed by thin layer chromatography and quantified with gas liquid chromatography. Gill accounted for the maximum accumulation of fenvalerate followed by muscle and liver. Enzyme assay indicated an increased activity of lactate dehydrogenase, whereas the activity of succinate dehydrogenase decreased continuously up to 96 h in all selected tissues. The alteration in the activity of these enzymes in the fish treated with fenvalerate might be due to the severe cellular damage leading to the release of these enzymes and impaired carbohydrate and protein metabolism.
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