The influence of salt, temperature, and deuterium oxide on the self-aggregation of n-nonyl-beta-D-glucoside (beta-C9G1) in dilute solution has been investigated by static and dynamic light scattering, neutron scattering, and tensiometry. Scattering data show that the micelles can be described as relatively stiff, elongated structures with a circular cross section. With a decrease of temperature, the micelles grow in one dimension, which makes it surprising that the critical micelle concentration (cmc) shows a concomitant increase. On the other hand, substitution of D2O for H2O causes a large increase in micelle size at low temperatures, without any appreciable effect on cmc. With increasing temperature, the deuterium effect on the micelle size diminishes. The effects of salt on the micelle size and cmc were found to follow the Hofmeister series. Thus, at constant salt concentration, the micelle size decreased according to the sequence SO4(2-) > Cl- > Br- > NO3- > I- > SCN-, whereas the effect on cmc displays the opposite trend. Here, I- and SCN are salting-in anions. Similarly, the effects of cations decrease with increasing polarizability in the sequence Li+ > Na+ > K+ > Cs+. At high ionic strength, the systems separate into two micellar phases. The results imply that the size of beta-C9G1 micelles is extremely sensitive to changes in the headgroup size. More specifically, temperature and salt effects on effective headgroup size, including intermolecular interactions and water ofhydration, are suggested to be more decisive for the micelle morphology than the corresponding effects on unimer solubility.

Download full-text PDF

Source
http://dx.doi.org/10.1021/la035613eDOI Listing

Publication Analysis

Top Keywords

micelle size
16
temperature salt
8
deuterium oxide
8
oxide self-aggregation
8
dilute solution
8
temperature deuterium
8
headgroup size
8
size
7
micelle
6
effects
5

Similar Publications

Micellar casein were constructed to improve the encapsulation efficiency of algae oil docosahexaenoic acid by transglutaminase-coupled phosphoserine peptide chelating with Ca.

Int J Biol Macromol

January 2025

College of Food and Nutrition, Joint Research Center for Food Nutrition and Health of IHM, Anhui Agriculture University, Hefei, Anhui 230036, China. Electronic address:

Micelle systems using safe food-grade biopolymers are of particular interest for the encapsulation and delivery of nutrition components. Micellar casein (MC) was assembled using transglutaminase (TGase) to couple with phosphoserine peptide, which enhance the stability of docosahexaenoic acid (DHA) from algae oil. The mechanism behind the construction of MC-phosphoserine peptide and the encapsulation of DHA was explored.

View Article and Find Full Text PDF

Visible Light-Responsive Composition-Dependent Morphology and Cargo Release in Mixed Micelles of Dendron Amphiphiles.

Langmuir

January 2025

Polymer Science and Engineering Division, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411008, India.

2,2-Bis-(methylol)propionic acid-based second-generation polyester dendron amphiphile (T-D) containing visible light-responsive donor-acceptor Stenhouse adduct (DASA) as hydrophobic tails is synthesized. Micelles of T-D amphiphile and its mixed micelles of varying compositions with nonresponsive dendron amphiphile containing lauryl groups are prepared in aqueous solution. In transmission electron microscopy and atomic force microscopy analyses, T-D amphiphiles show rice grain-like ellipsoidal micelles as the predominant morphology.

View Article and Find Full Text PDF

Block copolymers (BCPs) can form nanoparticles having different morphologies that can be used as photonic nanocrystals and are a platform for drug delivery, sensors, and catalysis. In particular, BCP nanoparticles having disk-like shape have been recently discovered. Such nanodisks can be used as the next-generation antitumor drug delivery carriers; however, the applicability of the existing nanodisks is limited due to their poor or unknown ability to respond to external stimuli.

View Article and Find Full Text PDF

Targeted Delivery of BMS-1166 for Enhanced Breast Cancer Immunotherapy.

Int J Nanomedicine

January 2025

College of Science, Mathematics and Technology, Wenzhou-Kean University, Wenzhou, Zhejiang, People's Republic of China.

Background: Cancer immunotherapy has achieved great success in breast cancer treatment in recent years. The Programmed Death-1 (PD-1) /Programmed Death-Ligand 1 (PD-L1) immune checkpoint pathway is among the most studied. BMS-1166, a PD-L1 inhibitor, can interfere with PD-1 and PD-L1 interaction.

View Article and Find Full Text PDF

Due to the escalating threat of the pathogens' capability of quick adaptation to antibiotics, finding new alternatives is crucial. Although antimicrobial peptides (AMPs) are highly potent and effective, their therapeutic use is limited' as they are prone to enzymatic degradation, are cytotoxic and have low retention. To overcome these challenges, we investigate the complexation of the cationic AMP colistin with diblock copolymers poly(ethylene oxide)--poly(methacrylic acid) (PEO--PMAA) forming colistin-complex coacervate core micelles (colistin-C3Ms).

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!