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Basic Science and Pathogenesis.
Alzheimers Dement
December 2024
University of Michigan School of Public Health, Ann Arbor, MI, USA.
Background: The ε4 allele of the apolipoprotein E (APOE) gene is the strongest genetic determinant for Alzheimer's disease and cognitive function in nearly all human populations, yet inconsistent effects have been reported in South Asians. The population of India has admixed genetic ancestry with most people falling on a North/South cline and having varying proportions of Ancestral North Indian (ANI) and Ancestral South Indian (ASI) ancestries, and those in east of India fall off the cline due to ancestry from additional ancestral populations. This study examined the ε4 association with cognitive function across 18 states/union territories of India and investigated whether ancestral background modulates ε4 association with cognitive function in 2,590 participants from the Longitudinal Aging Study in India - Diagnostic Assessment of Dementia (LASI-DAD).
View Article and Find Full Text PDFBasic Science and Pathogenesis.
Alzheimers Dement
December 2024
University of Michigan School of Public Health, Ann Arbor, MI, USA.
Background: The prevalence of dementia in India is approximately 7.4% among those aged 60 years and older, yet little is known about genetic risk factors for dementia in this population. Examining genetic variants at higher frequency in India than other ancestries (i.
View Article and Find Full Text PDFClinical Manifestations.
Alzheimers Dement
December 2024
Columbia University Irving Medical Center, New York, NY, USA.
Background: Some research suggests that multilingualism confers a cognitive advantage, but this association may be confounded by linguistic and socioeconomic factors. Multilinguals can differ on their first language such that it could be a societal majority- or minority-language, resulting in distinct reasons for- and experiences with- becoming/being multilingual, along with different socioeconomic opportunities. We evaluated the association of multilingualism (Monolingual, Multilingual-Majority, Multilingual-Minority) and socioeconomic status (SES) on cognition among older adults.
View Article and Find Full Text PDFClinical Manifestations.
Alzheimers Dement
December 2024
Centre for Brain Research, Indian Institute of Science, Bangalore, Karnataka, India.
Background: Dementia, a global health challenge, drives the need for comprehensive understanding. Longitudinal cohort studies are vital, yet maintaining follow-up in dementia cohorts poses challenges. This study explores challenges in follow-up, refines protocols, and develops strategies that can elevate dementia research quality.
View Article and Find Full Text PDFThe Experiences of Hijab and Non-Hijab-Wearing Muslim Women Students: Exploring Social Isolation and Discrimination in Delhi, India.
J Community Psychol
January 2025
Department of Psychology, Jamia Millia Islamia, New Delhi, India.
Research suggests that Muslim women wearing the hijab may be particularly vulnerable to the experiences of stigmatization as the hijab represents a dominant marker of "otherness." Using the relational demography perspective, this paper explored the viewpoints of hijab and non-hijab-wearing Muslim women in Delhi regarding the different forms of discrimination and/or social isolation they may have experienced. Thematic analysis was used to explore the participant's narratives, gathered by means of six focus group discussions (n = 38).
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