The authors studied the use of comprehensive individual tuberculin diagnosis (scarification skin test, intradermal titer) in the differential diagnosis of the nature of tuberculin sensitivity in children referred for examinations by physiological pediatricians for the diagnosis of a turn of tuberculin tests and the formation of registry group VIA. The use of this procedure was found to avoid the hyperdiagnosis of a turn of tuberculin tests in as high as 55.8%, to improve the diagnosis of hyperergic reactions to tuberculin, and to detect an occult false hyperergic reaction. Moreover, there is a possibility of observing the changes in individual sensitivity in Registry Group 0 children, which contributes to their more timely transfer to Group VIA. Analyzing the results shows that the use of comprehensive tuberculin diagnosis promotes the optimization of a system of preventive measures aimed at preventing tuberculosis in children.
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J Am Soc Nephrol
January 2025
Division of Tuberculosis Elimination, Centers for Disease Control and Prevention, Atlanta, Georgia.
Background: People with chronic kidney disease (CKD) have a higher risk for progression to tuberculosis disease following infection with Mycobacterium tuberculosis. We produced a nationwide incidence estimate and description of tuberculosis among people with kidney failure.
Methods: We completed a cross-sectional descriptive analysis of people with a reported case of tuberculosis in the United States between 2010 and 2021.
Retina
February 2025
Disha Eye Hospitals Pvt Ltd, Barrackpore, India.
Purpose: To develop a simple tool to remove retained submacular perfluorocarbon liquid bubbles (R-PFCL) and to inject recombinant tissue plasminogen activator safely in subretinal space in submacular hematomas.
Method: A retrospective, interventional study was performed where a simple homemade micro-viscous fluid control was developed to gain access to subretinal space in a controlled way. The rubber cap of the plunger of a 1-mL syringe was cut; this cut rubber cap of the plunger was fitted inside an empty 1-mL tuberculin syringe, and its end was fitted with the tubings of viscous fluid control of the vitrectomy machine.
Eur J Pediatr
January 2025
Infectious Diseases Unit, Department of Health Sciences, Anna Meyer Children's University Hospital, University of Florence, Florence, Italy.
Purpose: High-accuracy diagnostic screening tests for Mycobacterium tuberculosis (MTB) infection are required, primarily to detect patients with latent infections (LTBIs) in order to avoid their progression to active tuberculosis disease. The performance of the novel IGRA LIOFeron®TB/LTBI was evaluated in children. The originality of this test is the new MTB antigen contained (L-alanine dehydrogenase), identified as a tool to differentiate active TB from LTBI infection.
View Article and Find Full Text PDFRev Argent Microbiol
January 2025
Servicio de Microbiología, Universidad Católica de Córdoba, Clínica Universitaria Reina Fabiola, Córdoba, Argentina. Electronic address:
The WHO aims to reduce the number of deaths from TB by 95% and decrease its incidence rate by 90% between 2015 and 2035. The recommended rapid diagnostic tests are accurate and cost-effective, allow for a prompt start to treatment, and influence other outcomes that are important to the patient. To detect latent infection, the tuberculin skin test and interferon γ release (IGRA) tests are used.
View Article and Find Full Text PDFSao Paulo Med J
January 2025
Adjunt Professor, College of Medicine, Universidade Federal do Vale do São Francisco (UNIVASF), Paulo Afonso (BA), Brazil.
Background: The diagnosis and treatment of latent tuberculosis infection (LTBI) are crucial for tuberculosis (TB) control. Household contacts (HHC) of patients with pulmonary TB are at a high risk of LTBI due to their close proximity to source cases.
Objective: To describe the diagnosis and treatment of LTBI among HHC.
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