The authors report a case of intra-abdominal synovial sarcoma in a 41-year-old female. The tumor, which had an unusual location, the ascending mesocolon, had a mono-phasic spindle cell pattern. Immunohistochemical positivity for the epithelial membrane antigen (EMA) and cytokeratin AE1/AE3 differentiated the lesion from other spindle cell sarcomas with similar histology. The pathological and clinical features of the entity are briefly discussed.
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