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Relationship Between Antibiotic Resistance, Biofilm Formation, and Biofilm-Specific Resistance in Isolates from Ningbo, China.
Infect Drug Resist
June 2022
Department of Dermatology, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen, 518004, People's Republic of China.
Purpose: Several pathotypes still constitute an important public health concern owing to its pathogenicity and antimicrobial resistance. Moreover, biofilm formation of can allow the strains to interfere with host and antimicrobial eradication, thus conferring additional resistance. The association between the formation of biofilm and antimicrobial resistance determinants has been extensively exploited; nevertheless, there is still no definite conclusion.
View Article and Find Full Text PDFConformational adaptability determining antibody recognition to distomer: structure analysis of enantioselective antibody against chiral drug gatifloxacin.
RSC Adv
December 2021
Guangdong Provincial Key Laboratory of Food Quality and Safety, College of Food Science, South China Agricultural University Guangzhou 510642 China
Enantioselective antibodies have great potential to separate and detect chiral compounds. However, cross-reactivity of enantioselective antibodies to the distomer may limit the application. An in-depth understanding of interactions between antibodies and chiral drugs could be helpful to investigate antibody recognition to the distomer.
View Article and Find Full Text PDFCharacterization of melt-quenched and milled amorphous solids of gatifloxacin.
Drug Dev Ind Pharm
November 2016
a Faculty of Pharmacy , Research Institute of Pharmaceutical Sciences, Musashino University, Nishitokyo-shi , Tokyo , Japan.
The objectives of this study were to characterize and investigate the differences in amorphous states of gatifloxacin. We prepared two types of gatifloxacin amorphous solids coded as M and MQ using milling and melt-quenching methods, respectively. The amorphous solids were characterized via X-ray diffraction (XRD), nonisothermal differential scanning calorimetry (DSC) and time-resolved near-infrared (NIR) spectroscopy.
View Article and Find Full Text PDFDevelopment of gatifloxacin-loaded cationic polymeric nanoparticles for ocular drug delivery.
Pharm Dev Technol
March 2016
a Faculty of Medical and Health Sciences , School of Pharmacy, The University of Auckland, Auckland , New Zealand .
The present investigation aimed at improving the ocular bioavailability of gatifloxacin by prolonging its residence time in the eye and reducing problems associated with the drug re-crystallization after application through incorporation into cationic polymeric nanoparticles. Gatifloxacin-loaded nanoparticles were prepared via the nanoprecipitation and double emulsion techniques. A 50:50 Eudragit® RL and RS mixture was used as cationic polymer with other formulation parameters varied.
View Article and Find Full Text PDFA new multicomponent salt of imidazole and tetrabromoterepthalic acid: structural, optical, thermal, electrical transport properties and antibacterial activity along with Hirshfeld surface analysis.
Spectrochim Acta A Mol Biomol Spectrosc
June 2015
Department of Physics, Jadavpur University, Kolkata 700032, India. Electronic address:
Herein, we report the structural, optical, thermal and electrical transport properties of a new multicomponent salt (TBTA(2-))·2(IM(+))·(water) [TBTA-IM] of tetrabromoterepthalic acid (TBTA) with imidazole (IM). The crystal structure of TBTA-IM is determined by both the single crystal and powder X-ray diffraction techniques. The structural analysis has revealed that the supramolecular charge assisted O(-)⋯HN(+) hydrogen bonding and Br⋯π interactions play the most vital role in formation of this multicomponent supramolecular assembly.
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