AI Article Synopsis
- A study involved 20 patients with allergic rhinitis and/or asthma sensitized to a common allergen, Dermatophagoides pteronyssinus, who underwent both methacholine and allergen bronchial challenges over two days.
- After a 72-hour period post allergen challenge, a fiberoptic bronchoscopy with bronchial and bronchoalveolar lavage (BAL) was performed to collect cell differentials and measure specific IgE antibodies.
- Results indicated that patients with a dual response to allergens had higher levels of antigen-specific IgE antibodies in their bronchoalveolar lavage compared to those with an isolated early response, although serum IgE levels were similar across both groups.
Article Abstract
Twenty patients with allergic rhinitis and/or asthma sensitised to Dermatophagoides pteronyssinus were studied. On two consecutive days they underwent methacholine challenge and allergen bronchial challenge. 72 h after allergen challenge, fibreoptic bronchoscopy with bronchial (BL) and bronchoalveolar (BAL) lavage was performed. Specific IgE antibodies were measured both in serum and in BL from 14 patients. Both BAL and BL cell differentials were similar in patients with isolated early response to allergen and in patients with dual response. Patients with dual response to allergen showed higher levels of antigen specific IgE antibodies in BL than patients with isolated early response, while IgE levels in serum were similar in the two groups.
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| http://dx.doi.org/10.1159/000196093 | DOI Listing |
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