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Transforming Bacterial Pathogens into Wonder Tools in Cancer Immunotherapy.
Mol Ther
January 2025
College of Veterinary Medicine, Jeonbuk National University, 79 Gobong-ro, Iksan City, Jeollabuk-do, 54596, Republic of Korea. Electronic address:
Cancer immunotherapy has revolutionized cancer treatment due to its precise, target-specific approach compared to conventional therapies. However, treating solid tumors remains challenging as these tumors are inherently immunosuppressive, and their tumor microenvironment (TME) often limits therapeutic efficacy. Interestingly, certain bacterial species offer a promising alternative by exhibiting an innate ability to target and proliferate within tumor environments.
View Article and Find Full Text PDFCRISPR challenges in clinical developments.
Prog Mol Biol Transl Sci
January 2025
Department of Biochemistry, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.
CRISPR-Cas (clustered regularly interspaced short palindromic repeats and associated proteins) is a novel genome editing technology with potential applications in treating diseases. Currently, its use in humans is restricted to clinical trials, although its growth rate is significant, and some have received initial FDA approval. It is crucial to examine and address the challenges for this technology to be implemented in clinical settings.
View Article and Find Full Text PDFApplication prospect of polysaccharide in the development of vaccine adjuvants.
Int J Biol Macromol
January 2025
Department of Pharmacognosy and Utilization Key Laboratory of Northeast Plant Materials, School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address:
Vaccination is an effective strategy for preventing infectious diseases. Subunit vaccines offer more precise targeting and safer protection compared with traditional inactivated virus vaccines. However, due to their poor immunogenicity, subunit vaccines necessitate the use of adjuvants to stimulate the immune system.
View Article and Find Full Text PDFAlginate-based materials as adsorbent for sustainable water treatment.
Int J Biol Macromol
January 2025
Centre for Advanced Composite Materials, Universiti Teknologi Malaysia (UTM), Johor Bahru 81310, Malaysia.
With the encroaching issue of water pollution, the use of involved chemicals to remove pollutants from water is not only a risk of chemical contamination, a potential hazard to the environment and human health but also requires significant investment in managing and improving the chemicals. Therefore, alginate as one of the nanomaterial-adorned polysaccharides-based entity that usually extract from brown algae has been used as novel and more efficient catalysts in the removal of a variety of aqueous pollutants from wastewater, including ionic metals and organic/inorganic pollutants by using the adsorption techniques. Adsorption is a technique used in water treatment where non-polar or particles less soluble in water are stuck to the surface of the adsorbent and therefore purifying it.
View Article and Find Full Text PDFTwo-photon photosensitizer for specific targeting and induction of tumor pyroptosis to elicit systemic immunity-boosting anti-tumor therapy.
Biomaterials
January 2025
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, 361102, China. Electronic address:
Photodynamic therapy (PDT) has garnered increasing attention in cancer treatment due to its precise spatiotemporal selectivity and non-invasive nature. However, several challenges, including the inability of photosensitizers to discriminate between tumor and healthy tissues, as well as the limited tissue penetration depth of light sources, impede its broader application. To surmount these impediments, our research introduces a two-photon photosensitizer (TPSS) that specifically targets tumor overexpressing carbonic anhydrase IX (CA IX), thereby exhibiting exceptional specificity for tumor cells.
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