Statistical inference for relative potency in bivariate dose-response assays with correlated responses.

J Biopharm Stat

Eli Lilly & Company, Lilly Corporate Center, Global Statistical Sciences, Indianapolis, IN 46285, USA.

Published: July 2005

The analysis of dose-response assays measuring two correlated responses is considered. Attention is given to statistical inference for the potency ratio. Results from a simulation study suggest that a post hoc adjustment for the correlation in parameter estimates obtained from univariate fits provides nearly as much power to detect differences in potency as a bivariate response model fit.

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http://dx.doi.org/10.1081/BIP-200048798DOI Listing

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