The analysis of dose-response assays measuring two correlated responses is considered. Attention is given to statistical inference for the potency ratio. Results from a simulation study suggest that a post hoc adjustment for the correlation in parameter estimates obtained from univariate fits provides nearly as much power to detect differences in potency as a bivariate response model fit.
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http://dx.doi.org/10.1081/BIP-200048798 | DOI Listing |
Pediatr Res
January 2025
Heart Center, Women and Children's Hospital, Qingdao University, Qingdao, China.
Background: Despite prior observational studies suggesting a link between gut microbiota to Kawasaki disease (KD), these findings remain debated. This study aimed to assess the association between gut microbiota and KD on a genetic level using a two-sample Mendelian randomization (MR) analysis.
Methods: This two-sample MR analysis utilized summary statistics from the largest genome-wide association study meta-analysis on gut microbiota conducted by the MiBioGen consortium.
Stat Med
February 2025
U.S. Food and Drug Administration, Silver Spring, Maryland.
The recent U.S. Food and Drug Administration guidance on complex innovative trial designs acknowledges the use of Bayesian strategies to incorporate historical information based on clinical expertise and data similarity.
View Article and Find Full Text PDFInt J Mol Sci
January 2025
School of Mathematics and Computer Science, Gannan Normal University, Ganzhou 341000, China.
Due to advances in big data technology, deep learning, and knowledge engineering, biological sequence visualization has been extensively explored. In the post-genome era, biological sequence visualization enables the visual representation of both structured and unstructured biological sequence data. However, a universal visualization method for all types of sequences has not been reported.
View Article and Find Full Text PDFParasitol Int
January 2025
Parasitology Department, Faculty of Veterinary Medicine, Mansoura University, Mansoura 35516, Egypt. Electronic address:
Background/objective: Theileria orientalis is a non-transforming Theileria species infecting cattle and water buffaloes. Several outbreaks of oriental theileriosis accompanied by considerable economic loss were documented in Asia, Australia, and New Zealand. The major piroplasm surface protein (MPSP) gene has frequently been used to molecularly characterize T.
View Article and Find Full Text PDFHear Res
December 2024
Leibniz Institute for Neurobiology, Research Group Comparative Neuroscience, Magdeburg, Germany; Department of Psychology, Lancaster University, Lancaster, UK.
Adaptation is the attenuation of a neuronal response when a stimulus is repeatedly presented. The phenomenon has been linked to sensory memory, but its exact neuronal mechanisms are under debate. One defining feature of adaptation is its lifetime, that is, the timespan over which the attenuating effect of previous stimulation persists.
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