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Cloning, Expression, Characterization and in silico studies of L-asparaginase from Vibrio sp. (GBPx3).
Biochimie
March 2025
Department of Medical Biotechnology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran; Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran. Electronic address:
L-asparaginase is a critical therapeutic enzyme for treating acute lymphoblastic leukemia (ALL), a common childhood malignancy. In this study, the L-asparaginase coding sequence from halophilic Vibrio sp. (GBPx3) was cloned, expressed in Escherichia coli, and characterized.
View Article and Find Full Text PDFAltered markers of brain metabolism and excitability are associated with executive functioning in young children exposed to alcohol in utero.
Metab Brain Dis
November 2024
Department of Radiology, University of Calgary, 28 Oki Drive NW, Calgary, T3B 6A8, AB, Canada.
Article Synopsis
- Prenatal alcohol exposure (PAE) is a major cause of birth defects and cognitive issues, particularly affecting brain development and executive functions in children aged 3-8 years.
- The study used magnetic resonance spectroscopy (MRS) to analyze brain metabolites in children with PAE compared to unexposed children, revealing elevated levels of total choline (tCho) and glutamate + glutamine (Glx) in certain brain regions.
- The findings suggest that altered brain metabolism in children with PAE is linked to their cognitive performance, with higher tCho associated with better executive function, while elevated Glx correlates with poorer inhibitory control specifically in the PAE group.
Risk of celiac disease autoimmunity is modified by interactions between CD247 and environmental exposures.
Sci Rep
October 2024
Celiac Disease Research Center, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Season of birth, viral infections, HLA haplogenotypes and non-HLA variants are implicated in the development of celiac disease and celiac disease autoimmunity, suggesting a combined role of genes and environmental exposures. The aim of the study was to further decipher the biological pathways conveying the season of birth effect in celiac disease autoimmunity to gain novel insights into the early pathogenesis of celiac disease. Interactions between season of birth, genetics, and early-life environmental factors on the risk of celiac autoimmunity were investigated in the multicenter TEDDY birth cohort study.
View Article and Find Full Text PDFTranscriptomic and Proteomic Insights into Host Immune Responses in Pediatric Severe Malarial Anemia: Dysregulation in HSP60-70-TLR2/4 Signaling and Altered Glutamine Metabolism.
Pathogens
October 2024
Center for Global Health, Internal Medicine, University of New Mexico, Albuquerque, NM 87131, USA.
Severe malarial anemia (SMA, Hb < 6.0 g/dL) is a leading cause of childhood morbidity and mortality in holoendemic transmission zones. This study explored the entire expressed human transcriptome in whole blood from 66 Kenyan children with non-SMA (Hb ≥ 6.
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