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Long-term complications, survival and mortality in splenectomised adult transfusion-dependent thalassemia patients.
Transfus Apher Sci
January 2025
Department of Clinical Hematology and Medical Oncology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Background: Splenectomy is frequently performed in transfusion-dependent thalassemia (TDT) patients to lower blood transfusion needs but is associated with significant long-term complications, including sepsis, thrombosis, and pulmonary hypertension. This study examines the long-term complications, survival rates, and causes of mortality among adult patients with TDT who have undergone splenectomy in a low and middle-income country (LMIC).
Methods: A retrospective analysis was conducted on 103 adult TDT patients (≥18 years) who underwent splenectomy between July 2013 and March 2024.
A Systematic Approach to Reduce Blood Transfusions in Acute Type A Aortic Dissection Surgery.
Int Heart J
December 2024
Department of Cardiovascular Surgery, The Second Hospital of Jilin University.
This study aimed to summarize our experience using a systematic approach to reduce blood transfusions in acute type A aortic dissection (ATAAD) surgery.From August 2016 to June 2020, 326 patients underwent ATAAD surgery in our center employing a systematic approach, which primarily included the following: Liu's aortic root repair technique, Liu's aortic arch inclusion technique with a frozen elephant trunk, moderate-to-mild hypothermia circulatory arrest, and application of centrifugal pump in cardiopulmonary bypass circuit. Patients were divided into two groups based on whether they had blood product transfusion during their hospital stay: transfusion group and transfusion-free group.
View Article and Find Full Text PDFIdentifying thresholds for meaningful improvements in NTDT-PRO scores to support conclusions about treatment benefit in clinical studies of patients with non-transfusion-dependent beta-thalassaemia: analysis of pooled data from a phase 2, double-blind, placebo-controlled, randomised trial.
BMJ Open
November 2024
Fondazione IRCCS Ca' Granda Policlinico Hospital, University of Milan, Milan, Italy.
Objectives: To estimate thresholds for defining meaningful within-patient improvement from baseline to weeks 13-24 and interpreting meaningfulness of between-group difference for the non-transfusion-dependent beta-thalassaemia patient-reported outcome (NTDT-PRO) tiredness/weakness (T/W) and shortness of breath (SoB) scores. A secondary objective was to determine the symptom severity threshold for the NTDT-PRO T/W domain to identify patients with symptomatic T/W.
Design: Pooled blinded data from the phase 2, double-blind, placebo-controlled, randomised BEYOND trial in NTDT (NCT03342404) were used.
A practical guide to reducing/eliminating red blood cell transfusions in the neonatal intensive care unit.
Semin Fetal Neonatal Med
October 2024
Division of Neonatology, Department of Pediatrics, University of Utah, 295 Chipeta Way, Salt Lake City, UT, 84108, USA; Women and Newborns Research, Intermountain Health, Murray, UT, USA.
Article Synopsis
- * Common risks include worsening inflammatory issues and potential long-term effects like retinopathy of prematurity and neurodevelopmental delays, which are sometimes not fully addressed during the informed consent process.
- * Implementing non-drug methods to avoid transfusions, alongside erythropoietic stimulating agents, can significantly reduce the need for transfusions in NICU patients, making care both more effective and cost-efficient.
Effect of high-dose intravenous iron injection on hepatic function in a rat model of cirrhosis.
J Int Med Res
May 2024
Department of Anesthesiology and Pain Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Objective: To investigate the hepatic effects of high-dose intravenous (IV) iron, including those on liver function and the degree of fibrosis, in a rat model of cirrhosis.
Methods: We evenly allocated 25 Sprague-Dawley rats into five groups: normal rats (control group), cirrhotic rats receiving IV normal saline (liver cirrhosis [LC] group), and cirrhotic rats receiving 20, 40, or 80 mg/kg IV ferric carboxymaltose (LC-iron20, LC-iron40, and LC-iron80 group, respectively). Biochemical parameters were compared at 0, 7, 14, 21, and 28 days.
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