AI Article Synopsis
- Genes can be regulated at translational checkpoints, which is a key part of posttranscriptional regulation.
- Inflammatory and vascular cells respond to external signals that affect the translation of specific messenger RNAs, impacting cellular characteristics.
- Dysregulation of these pathways and the proteins they influence is linked to cardiovascular diseases, making them potential targets for therapy.
Article Abstract
The expression of a subset of genes is strongly controlled at translational checkpoints, a major mechanism of posttranscriptional regulation. Inflammatory and vascular cells receive outside-in signals to specialized pathways that regulate translation of specific messenger RNAs in a transcript-specific fashion and thereby influence key features of cellular phenotype. These pathways and the expression of proteins that they control may be dysregulated in cardiovascular diseases and are therapeutic targets.
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| http://dx.doi.org/10.1016/j.tcm.2004.10.004 | DOI Listing |
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