Objective: To investigate the changing of T4 5'-and 5-deiodinase within rat brain under various iodin-nutritional states.
Methods: Animal model of iodine-deficiency rat was performed and the rats were divided into 4 groups by the intake of iodine-nutrition, and then killed at an age of 20 days. The thyroid hormones level in serum was measured by ELISA and the activity of T(4) 5'-and 5-deiodinase within brain was analyzed.
Results: In less-iodine (LI) group,TT4 and FT4 were accounting for 3.5% of the neutral-iodine (NI) group's, and FT3 was 174.0% of NI group's (P < 0.05). In NI group,TT4 and FT4 were 114.5% and 127.7% of NI group's (P < 0.05). In high-iodine (HI) group, TT4 and FT4 were 61.86% and 62.0% of NI group's, and FT3 was 184.9% of NI group's (P < 0.05). In LI group, the activity of T4 5'-deiodinase tissue of per gram (1.95 +/- 0.32) ngT3.microgT4(-1).h was significantly higher than that of NI group (P < 0.05), and the activity of 5-deiodinase (1.38 +/- 0.21) ngrT3.microg T4(-1).h(-1) is significantly less than that of NI group (1.59 +/- 0.23) (P < 0.05). In HI group the activity of T4 5'-and 5-deiodinase tissue of per gram (1.12 +/- 0.19 and 1.73 +/- 0.36) ngrT3.microgT4(-1).h(-1)was significantly less than that of NI group (P < 0.05).
Conclusion: The activity of T4 5'-deiodinase in iodine deficiency heightens and that in iodine excess is debased, the activity of T4 5-deiodinase in iodine deficiency and in iodine excess is debased.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Biochemical and Structural Characterisation of a Bacterial Lactoperoxidase.
Chembiochem
November 2024
GECCO Biotech, Zernikepark 6, 9747 AN, Groningen, The Netherlands.
Peroxidases belong to a group of enzymes that are widely found in animals, plants and microorganisms. These enzymes are effective biocatalysts for a wide range of oxidations on various substrates. This work presents a biochemical and structural characterization of a novel heme-containing peroxidase from Cyanobacterium sp.
View Article and Find Full Text PDFEtomidate protects retinal ganglion cells from hydrogen peroxide-induced injury Nrf2/HO-1 pathway.
Int J Ophthalmol
September 2024
Department of Neurobiology, the Basic Medical Science Academy, the Fourth Military Medical University, Xi'an 710032, Shaanxi Province, China.
Aim: To determine whether etomidate (ET) has a protective effect on retinal ganglion cells (RGCs) injured with hydrogen peroxide (HO) and to explore the potential mechanism underlying the antioxidative stress effect of ET.
Methods: Cultured RGCs were identified by double immunofluorescent labeling of microtubule-associated protein 2 and Thy1.1.
Levothyroxine Treatment in Pregnant Women with Thyrotropin Levels Ranging Between 2.5 and 10 mIU/L: A Propensity Score Matched Analysis.
Thyroid
July 2024
Department of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, China.
Article Synopsis
- The study investigates the link between levothyroxine (LT4) treatment and adverse pregnancy outcomes in pregnant women with elevated TSH levels (2.5-10.0 mIU/L) during the first trimester, focusing on those with varying TPOAb statuses.
- Using a retrospective cohort analysis of 4,370 pregnant women, the research employed propensity score matching to compare outcomes between those treated with LT4 and those who were not.
- Findings revealed that LT4 treatment significantly reduced the risk of pregnancy loss but increased the likelihood of small-for-gestational-age infants and preterm birth, particularly among TPOAb-positive women with high-normal TSH levels.
Polymorphisms within DIO2 and GADD45A genes increase the risk of liver disease progression in chronic hepatitis b carriers.
Sci Rep
April 2023
Department of Photobiology and Molecular Diagnostics, Intercollegiate Faculty of Biotechnology, University of Gdansk and Medical University of Gdansk, Abrahama 58, 80-307, Gdansk, Poland.
The study enrolled 284 patients with chronic hepatitis B virus infection. Participants included people with mild fibrotic lesions (32.5%), moderate to severe fibrotic lesions (27.
View Article and Find Full Text PDFLongitudinal Associations Between Gene Variants and Thyroid Peroxidase Antibody Seroconversion in a Population-Based Study: Tehran Thyroid Study.
Genet Test Mol Biomarkers
March 2023
Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Autoimmune thyroid diseases (AITD) are usually accompanied by anti-thyroid antibodies which can serve as early predictive markers. This study was designed to investigate the relationship between thyroid peroxidase () gene variants and the presence of TPOAb and to evaluate the effect of environmental factors associated with seroconversion from TPOAb-negative to TPOAb-positive. Participants from phases 1 and 2 of the Tehran Thyroid Study in ( = 5327, ≥20 years) were evaluated in terms of TPOAb positivity, and its relationship with 53 single nucleotide polymorphisms (SNPs) from within the gene (cross-sectional approach).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!