Lactoferrin-induced cell depolarization and a delayed tobramycin-killing effect on Pseudomonas aeruginosa cells were correlated. This antibiotic tolerance effect (ATE) reflects the ability of a defense protein to modify the activity of an antibiotic as a result of its modulatory effect on bacterial physiology. P. aeruginosa isolates from cystic fibrosis patients showed higher ATE values (< or = 6-fold) than other clinical strains.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1068597 | PMC |
| http://dx.doi.org/10.1128/AAC.49.4.1613-1616.2005 | DOI Listing |
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