A new natural TEM derivative with extended-spectrum beta-lactamase activity, TEM-134, was identified in a ceftazidime-resistant clinical isolate of Citrobacter koseri. Compared to TEM-1, TEM-134 contains the following mutations: Q39K, E104K, R164H, and G238S. The bla(TEM-134) gene was not transferable by conjugation and, apparently, was chromosomally encoded. Expression studies with Escherichia coli revealed efficient cefotaximase and ceftazidimase activity for TEM-134.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1068604 | PMC |
| http://dx.doi.org/10.1128/AAC.49.4.1564-1566.2005 | DOI Listing |
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