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Relationship Between the Gut Microbiome, Tryptophan-Derived Metabolites, and Osteoarthritis-Related Pain: A Systematic Review with Meta-Analysis.
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Grupo de Investigación en Calidad de Vida y Salud, Departamento de Ciencias de la Salud, Universidad Europea de Valencia, 03016 Alicante, Spain.
Introduction: Osteoarthritis (OA) is the most prevalent form of arthritis and affects over 528 million people worldwide. Degenerative joint disease involves cartilage degradation, subchondral bone remodeling, and synovial inflammation, leading to chronic pain, stiffness, and impaired joint function. Initially regarded as a "wear and tear" condition associated with aging and mechanical stress, OA is now recognized as a multifaceted disease influenced by systemic factors such as metabolic syndrome, obesity, and chronic low-grade inflammation.
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School of Vehicle and Transportation Engineering, Taiyuan University of Science and Technology, Taiyuan 030024, China.
Aiming at the problems of a six-degree-of-freedom robotic arm in a three-dimensional multi-obstacle space, such as low sampling efficiency and path search failure, an improved fast extended random tree (RRT*) algorithm for robotic arm path planning method (abbreviated as HP-APF-RRT*) is proposed. The algorithm generates multiple candidate points per iteration, selecting a sampling point probabilistically based on heuristic values, thereby optimizing sampling efficiency and reducing unnecessary nodes. To mitigate increased search times in obstacle-dense areas, an artificial potential field (APF) approach is integrated, establishing gravitational and repulsive fields to guide sampling points around obstacles toward the target.
View Article and Find Full Text PDFIn Situ TEM Study of Electrical Property and Mechanical Deformation in MoS/Graphene Heterostructures.
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Department of Physical Science and Engineering, Nagoya Institute of Technology, Gokiso-cho, Showa-ku, Nagoya 466-8555, Japan.
We present a versatile method for synthesizing high-quality molybdenum disulfide (MoS) crystals on graphite foil edges via chemical vapor deposition (CVD). This results in MoS/graphene heterostructures with precise epitaxial layers and no rotational misalignment, eliminating the need for transfer processes and reducing contamination. Utilizing in situ transmission electron microscopy (TEM) equipped with a nano-manipulator and tungsten probe, we mechanically induce the folding, wrinkling, and tearing of freestanding MoS crystals, enabling the real-time observation of structural changes at high temporal and spatial resolutions.
View Article and Find Full Text PDFA Computational Model of Hybrid Trunk-like Robots for Synergy Formation in Anticipation of Physical Interaction.
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Robotic, Brain, and Cognitive Sciences Research Unit, Italian Institute of Technology, Center for Human Technologies, Via Enrico Melen 83, Bldg B, 16152 Genoa, Italy.
Trunk-like robots have attracted a lot of attention in the community of researchers interested in the general field of bio-inspired soft robotics, because trunk-like soft arms may offer high dexterity and adaptability very similar to elephants and potentially quite superior to traditional articulated manipulators. In view of the practical applications, the integration of a soft hydrostatic segment with a hard-articulated segment, i.e.
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Department of Frontier Surgery, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
Background: Early anal canal cancer is frequently treated with endoscopic submucosal dissection (ESD) to preserve anal function. However, if the lesion is in the anal canal, then significant difficulties such as bleeding and challenges associated with scope manipulation can arise.
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