The increasing complexity of the role of trainer, highlighted in the expectations of the Modernising Medical Careers curriculum, currently out for consultation, exposes inadequacies in the current system. Changes in the supervisory structure are required and further training is essential if consultants are to fulfil this role adequately.
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| http://dx.doi.org/10.12968/hmed.2005.66.3.17680 | DOI Listing |
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Protein prenylation in mechanotransduction: implications for disease and therapy.
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Department of Cardiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China. Electronic address:
The process by which cells translate external mechanical cues into intracellular biochemical signals involves intricate mechanisms that remain unclear. In recent years, research into post-translational modifications (PTMs) has offered valuable insights into this field, spotlighting protein prenylation as a crucial mechanism in cellular mechanotransduction and various human diseases. Protein prenylation, which involves the covalent attachment of isoprenoid groups to specific substrate proteins, profoundly affects the functions of key mechanotransduction proteins such as Rho, Ras, and lamins.
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Department of Chemistry, Center for Innovative Technology, Institute of Chemical Biology, Institute for Integrative Biosystems Research and Education, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, TN, United States. Electronic address:
Advancements in clinical chemistry have major implications in terms of public health, prompting many clinicians to seek out chemical information to aid in diagnoses and treatments. While mass spectrometry (MS) and hyphenated-MS techniques such as LC-MS or tandem MS/MS have long been the analytical methods of choice for many clinical applications, these methods routinely demonstrate difficulty in differentiating between isomeric forms in complex matrices. Consequently, ion mobility spectrometry (IM), which differentiates molecules on the basis of size, shape, and charge, has demonstrated unique advantages in the broad application of stand-alone IM and hyphenated IM instruments towards clinical challenges.
View Article and Find Full Text PDFClinical implications of maternal multikingdom transmissions and early-life microbiota.
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Department of Pediatrics, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China. Electronic address:
Mother-to-infant transmission of the bacteriome, virome, mycobiome, archaeome, and their mobile genetic elements has been recognised in nature as an important step for the infant to acquire and maintain a healthy early-life (from birth till age 3 years) microbiota. A comprehensive overview of other maternal multikingdom transmissions remains unavailable, except for that of the bacteriome. Associations between microorganisms and diseases throughout the human life span have been gradually discovered; however, whether these microorganisms are maternally derived and how they concomitantly interact with other microbial counterparts remain poorly understood.
View Article and Find Full Text PDFIdentifying public health competencies for Australian pharmacists: A modified Delphi study.
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Pharmacy, College of Medicine and Dentistry, James Cook University, Qld 4811, Australia.
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Environmental controls on the conversion of nutrients to chlorophyll in lakes.
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UK Centre for Ecology & Hydrology, Lake Ecosystems Group, Lancaster LA1 4AP, UK.
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