Improved results can be obtained by increasing the intensity of chemotherapy in patients with cancer. Prolonged granulocytopenia due to intensive chemotherapy schedules, however, is a frequent cause of infectious complications. Fungal infections, especially Aspergillus infections, are being recognized with increasing frequency. We describe an outbreak of invasive Aspergillus infections in six cancer patients treated with chemotherapy and we give an overview of the diagnostic and therapeutic dilemmas encountered in patients with invasive Aspergillus infection.
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Four-month-old infant with chronic granulomatous disease and invasive aspergillosis with bone involvement.
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Chronic granulomatous disease is the inborn error of immunity with the highest frequency of invasive aspergillosis. In this context, invasive aspergillosis is frequent in adolescence, with rare cases before one year of age. We present a case of chronic granulomatous disease and invasive aspergillosis in a four-month-old infant.
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Department of Pulmonary and Critical Care Medicine, Taihe Hospital, Hubei University of Medicine, Shiyan, 442000, Hubei, P.R. China.
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Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
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View Article and Find Full Text PDFConcordance of non-invasive plasma cell-free DNA with invasive diagnostics for diagnosis of invasive fungal disease.
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