AI Article Synopsis
- Germ-free mice were fed polysaccharide-rich or simple-sugar diets and colonized with Bacteroides thetaiotaomicron for 10 days, allowing researchers to study the bacteria's behavior.
- The bacteria attached to food and mucus, stimulated the production of specific proteins and enzymes, and preferred to consume simple sugars before switching to mucus when polysaccharides were scarce.
- This adaptable feeding strategy helps maintain ecological balance and supports functional diversity in the gut ecosystem.
Article Abstract
Germ-free mice were maintained on polysaccharide-rich or simple-sugar diets and colonized for 10 days with an organism also found in human guts, Bacteroides thetaiotaomicron, followed by whole-genome transcriptional profiling of bacteria and mass spectrometry of cecal glycans. We found that these bacteria assembled on food particles and mucus, selectively induced outer-membrane polysaccharide-binding proteins and glycoside hydrolases, prioritized the consumption of liberated hexose sugars, and revealed a capacity to turn to host mucus glycans when polysaccharides were absent from the diet. This flexible foraging behavior should contribute to ecosystem stability and functional diversity.
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| http://dx.doi.org/10.1126/science.1109051 | DOI Listing |
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