Background: CT colonography (CTC) is utilized as a diagnostic tool in the detection of colon polyps and early colorectal cancer in adults. Large studies in the literature, although focused on adult populations, have shown CTC to be a safe, accurate, non-invasive technique.
Objective: We evaluated the technical feasibility of CTC in children using a low-dose technique.
Materials And Methods: From November 2001 to April 2004 we evaluated eight patients (3-17 years) with non-contrast CTC. Seven of the patients had CTC, followed by standard colonoscopy (SC) the same day; in one patient, CTC followed a failed SC. CTC results were compared to results of SC. The estimated effective dose from each CTC was calculated and compared to that of standard barium enema.
Results: CTC results were consistent with those of SC. Sensitivity for polyps 5-10 mm was 100%, and sensitivity for polyps 10 mm and larger was 66.7%. The estimated mean effective dose was 2.17 mSv for CTC, compared to the 5-6 mSv for a standard air-contrast barium enema in a small child.
Conclusion: Our initial experience shows CTC in children is well-tolerated, safe, and useful. The procedure can be performed successfully with a low radiation dose, and preliminary results compare well with SC.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s00247-004-1394-2 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Production performance, serum lipid profile and gut health in Indian native Kadaknath chickens fed diet incorporated with liquorice root powder.
Heliyon
November 2024
Avian Nutrition and Feed Technology Division, Central Avian Research Institute, Izatnagar, 243 122, India.
The principal constituent of liquorice root () is glycyrrhizin, a triterpene saponin that is approximately many times sweeter than sucrose, the main active component. This study aimed to investigate the dietary liquorice root powder (LRP) on production performance, serum biochemical, gut health and carcass characteristics of Kadaknath (KN) birds as replacement of antibiotic growth promoter. Day-old Kadaknath chicks (n = 240) with uniform body weight were selected randomly and divided into six different treatments, each one with five replicates and eight birds per replicate, and raised in battery brooder cages for 15 weeks.
View Article and Find Full Text PDFGenome sequencing reveals novel variants in a diverse population with congenital anterior segment anomalies.
Sci Rep
January 2025
Department of Human Genetics, University of Miami Miller School of Medicine, Miami, FL, 33136, USA.
Congenital anterior segment anomalies are disorders that affect the development of the eye and cause severe visual impairment. The molecular basis of congenital anterior segment anomalies is not well known. In this study, genome sequencing was performed on 27 families from diverse ethnicities with congenital anterior segment anomalies and 11 variants were identified, most of which were novel and family specific.
View Article and Find Full Text PDFTumor cell-based liquid biopsy using high-throughput microfluidic enrichment of entire leukapheresis product.
Nat Commun
January 2025
Center for Engineering in Medicine and Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.
Circulating Tumor Cells (CTCs) in blood encompass DNA, RNA, and protein biomarkers, but clinical utility is limited by their rarity. To enable tumor epitope-agnostic interrogation of large blood volumes, we developed a high-throughput microfluidic device, depleting hematopoietic cells through high-flow channels and force-amplifying magnetic lenses. Here, we apply this technology to analyze patient-derived leukapheresis products, interrogating a mean blood volume of 5.
View Article and Find Full Text PDFImpact of anti-PD1 immunotherapy and circulating tumor cells on progression-free survival in surgical pancreatic adenocarcinoma: a retrospective cohort study.
Expert Rev Clin Immunol
January 2025
Department of Hepatobiliary, The Second Affiliated Hospital of Army Medical University, Chongqing, China.
Introduction: The clinical benefits of combining immunotherapy with chemotherapy and surgical resection in pancreatic adenocarcinoma remain unclear. The expression and clinical significance of HIF1A in circulating tumor cells (CTCs) in pancreatic adenocarcinoma remains limited.
Methods: This retrospective cohort study compared survival outcomes in pancreatic adenocarcinoma patients treated with two regimens: surgery+chemotherapy (nab-paclitaxel plus gemcitabine)+anti-PD1 (Tislelizumab) (S+AG+anti-PD1), and surgery+chemotherapy (S+AG).
Effects of Isalo scorpion cytotoxic peptide on growth, immune performance, and intestinal flora of yellow-feathered broilers.
Front Vet Sci
December 2024
Shihezi University, Collage of Animal Science & Technology, Xinjiang, China.
Introduction: This study aimed to investigate the effects of Isalo scorpion cytotoxic peptide (IsCT) on the growth performance, immune function, and gut microbiota of yellow-feathered broilers.
Methods: The experiment involved supplementing a corn-soybean meal-based diet with various dietary levels of IsCT. The experiment adopted a completely randomized design.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!