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Questioning the rules of engagement: a critical analysis of the use of limb symmetry index for safe return to sport after anterior cruciate ligament reconstruction.
Br J Sports Med
December 2024
Sahlgrenska Sports Medicine Center, Gothenburg, Sweden.
Objective: To evaluate the association between limb symmetry index (LSI) in quadriceps and hamstrings strength together with hop tests, as a proxy of recovery, and the deviation from being symmetrical (LSI 100%), with a safe return to sport (RTS) after anterior cruciate ligament reconstruction (ACL-R).
Methods: Athletes between 15 and 30 years old with a preinjury Tegner activity level ≥6 were eligible for inclusion. Data were extracted from a rehabilitation-specific registry, Project ACL (Gothenburg, Sweden) at the time of or after RTS for each athlete.
Prevention is the key.
Eur Heart J Cardiovasc Pharmacother
January 2025
Editor-in-Chief, Institute of Clinical Sciences, Karolinska Institute of Danderyd, Stockholm, Sweden.
Reply to the Letter to the Editor: ''The Need for a New Description of Red Flags in Cardiac Amyloidosis in Turkish Population''.
Turk Kardiyol Dern Ars
January 2025
Department of Cardiology, Eskişehir Osmangazi University Faculty of Medicine, Eskişehir, Türkiye.
An Open-Source Algorithm for Correcting Stress Wave Dispersion in Split-Hopkinson Pressure Bar Experiments.
Sensors (Basel)
January 2025
School of Mechanical, Aerospace & Civil Engineering, University of Sheffield, Sheffield S1 3JD, UK.
Stress wave dispersion can result in the loss or distortion of critical high-frequency data during high-strain-rate material tests or blast loading experiments. The purpose of this work is to demonstrate the benefits of correcting stress wave dispersion in split-Hopkinson pressure bar experiments under various testing situations. To do this, an innovative computational algorithm, SHPB_Processing.
View Article and Find Full Text PDFOptimized Prime Editing of Human Induced Pluripotent Stem Cells to Efficiently Generate Isogenic Models of Mendelian Diseases.
Int J Mol Sci
December 2024
Ocular Genomics Institute, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA.
Prime editing (PE) is a CRISPR-based tool for genome engineering that can be applied to generate human induced pluripotent stem cell (hiPSC)-based disease models. PE technology safely introduces point mutations, small insertions, and deletions (indels) into the genome. It uses a Cas9-nickase (nCas9) fused to a reverse transcriptase (RT) as an editor and a PE guide RNA (pegRNA), which introduces the desired edit with great precision without creating double-strand breaks (DSBs).
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