Objective: In our study, we evaluated the potential of micro-CT for the assessment of the rat knee joint using ex vivo micro-CT arthrography. The aims of the study were to introduce the technique of micro-CT arthrography and to visualize the normal anatomy of the rat knee. The secondary aims were the quantification of retropatellar cartilage thickness and the analysis of microstructural cancellous bone parameters within the tibial epiphysis.
Conclusion: Micro-CT arthrography is a novel technique for the indirect visualization of the distinct features and structural analysis of the rat knee joint. This technique represents an additional imaging and analysis tool in small-animal research.
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http://dx.doi.org/10.2214/ajr.184.4.01841215 | DOI Listing |
Bone
February 2023
Mayo Clinic Radiology, 4500 San Pablo Road, Jacksonville, FL 32224, United States of America.
In vivo micro-Computed Tomography (μCT) is commonly used tool in the study of mouse bone architecture. However, in vivo imaging of mouse cartilage has been limited. Intra-articular contrast injection was evaluated for its utility in detecting mouse cartilage in μCT.
View Article and Find Full Text PDFOsteoarthritis Cartilage
April 2019
Swiss BioMotion Lab, Department of Musculoskeletal Medicine, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne, Switzerland.
Objective: To test whether subchondral bone mineral density (sBMD) and cartilage thickness (CTh) of femoral condyles are correlated in knees without and with severe medial femorotibial osteoarthritis (OA), using a subregional analysis with computerized tomography (CT) arthrography.
Methods: CT arthrograms of 50 non-OA (18 males, 58.7 (interquartile range (IQR) = 6.
Osteoarthritis Cartilage
June 2016
Department of Radiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands. Electronic address:
Objective: Recently, computed tomography arthrography (CTa) was introduced as quantitative imaging biomarker to estimate cartilage sulphated glycosaminoglycan (sGAG) content in human cadaveric knees. Our aim was to assess the correlation between in vivo CTa in human osteoarthritis (OA) knees and ex vivo reference standards for sGAG and collagen content.
Design: In this prospective observational study 11 knee OA patients underwent CTa before total knee replacement (TKR).
Clin Exp Rheumatol
April 2016
Department of Rheumatology and Immunology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China.
Objectives: VX765, a potent and selective caspase-1 inhibitor, inhibits the release of IL-1, IL-18 and IL-33. In this study we investigated the effect of VX765 treatment on collagen-induced arthritis (CIA).
Methods: Twenty-four mice were randomly divided into three groups of 8: Normal (wild-type), CIA and VX765 (CIA with VX765 treatment) groups.
Bone
December 2015
Institute for Biomechanics, ETH Zurich, Zurich, Switzerland; SCANCO Medical AG, Bruttisellen, Switzerland. Electronic address:
Aim: Evidence suggests that subchondral bone can be used as a predictor for the onset of osteoarthritis. As such, there is a need to accurately and reproducibly quantify subchondral bone in areas where osteoarthritis develops. In this paper, we present a novel technique for the segmentation of subchondral bone in the tibiofemoral joint and assess the reproducibility of this method with multiple measures and users.
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