Heparin induced thrombocytopenia (HIT) is a rare, but potentially life-threatening complication of heparin therapy. In patients with HIT, alternative means of anticoagulation are necessary. The authors present an infant with HIT who required anticoagulation during cardiopulmonary bypass for tricuspid valve excision in the treatment of bacterial endocarditis. The direct thrombin inhibitor, argatroban, was successfully used. Previous reports regarding the use of argatroban and other nonheparin anticoagulants for anticoagulation are reviewed and suggestions regarding argatroban dosing in infants are presented.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/j.1460-9592.2005.01417.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Apixaban removal during emergency surgery for type A acute aortic dissection: a prospective cohort study.
Int J Surg
December 2024
Institute of Clinical Medicine, University of Oslo.
Background: Acute type A aortic dissection (ATAAD) has a high mortality, and acute aortic repair is the only curative treatment. In patients treated with factor Xa (FXa) inhibitors, the risk of severe disease-related complications such as cardiac tamponade and hemodynamic shock must be balanced against the potential for severe perioperative bleeding. The aim was to study intraoperative changes in plasma levels of the FXa inhibitor apixaban when using hemoadsorption during acute thoracic aortic repair.
View Article and Find Full Text PDFInadequate Anti-Factor Xa Levels With Daily 40-mg Enoxaparin After Cardiac Surgery.
Ann Thorac Surg Short Rep
September 2024
Department of Cardiovascular and Thoracic Surgery, Zucker School of Medicine at Hofstra/Northwell, Manhasset, New York.
Background: Cardiac surgery patients are at increased risk for venous thromboembolism (VTE). Prevention is the most critical strategy to reduce VTE-associated morbidity and death. However, there is a lack of data on the optimal approach to VTE prophylaxis in this population of high-risk patients.
View Article and Find Full Text PDFEstablishing an Extracorporeal Cardiopulmonary Resuscitation Program.
Medicina (Kaunas)
December 2024
Department of Health Science, Anesthesia and ICU, School of Medicine, University of Basilicata San Carlo Hospital, 85100 Potenza, Italy.
Extracorporeal cardiopulmonary resuscitation (ECPR) is a complex, life-saving procedure that uses mechanical support for patients with refractory cardiac arrest, representing the pinnacle of extracorporeal membrane oxygenation (ECMO) applications. Effective ECPR requires precise patient selection, rapid mobilization of a multidisciplinary team, and skilled cannulation techniques. Establishing a program necessitates a cohesive ECMO system that promotes interdisciplinary collaboration, which is essential for managing acute cardiogenic shock and severe pulmonary failure.
View Article and Find Full Text PDFMilky White Supernatant in the Cardiopulmonary Bypass Circuit in Severe Hypertriglyceridemia During Pediatric Cardiac Surgery: A Case Report.
World J Pediatr Congenit Heart Surg
January 2025
Anaesthesiology, Critical Care and Pain Medicine, All India Institute of Medical Sciences - Guwahati, Guwahati, India.
Article Synopsis
- The case involves a 21-month old girl with severe hypertriglyceridemia during cardiac surgery for a ventricular septal defect.
- A milky liquid was found in the bypass circuit, leading to tests that confirmed high triglycerides, necessitating careful management during surgery.
- The child recovered well, demonstrating the importance of quickly recognizing and addressing hypertriglyceridemia to prevent complications in pediatric heart operations.
Hemadsorption with CytoSorb®: focus on the latest experiences in cardiac surgery patients.
J Artif Organs
December 2024
Division of Cardiology, Ospedale Civile Maggiore Borgo Trento, Piazzale Stefani, Verona, (VR), Italy.
Cardiac surgery patients are potentially exposed to an acute inflammatory host response with a huge release of both pro- and anti-inflammatory cytokines both through intrinsic (e.g., tissue damage, endothelial injury) and extrinsic (e.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!